Low Sodium Chloride Diet may increase chances of atherosclerosis and cardiac hypertrophy
Dear Editor,
According to Harrison's Principles of Internal Medicine, 17th
Edition, volume 2, Page 1552:
In response to low sodium chloride diet, arterial pressure and volume
homeostasis may be maintained by increased activity of renin-angiotensin-
aldosterone axis. However, independent of its hemodynamic effect,
angiotensin II may play a role in the pathogenesis of atherosclerosis
through a direct action on the vessel walls. On the other hand,
independent of its potential effect on blood pressure, aldosterone may
also play role in cardiac hypertrophy. Aldosterone acts via
mineralocorticoid receptor within the myocardium to enhance extracellular
matrix and collegen diposition. Pathologic patterns of left ventricular
geometry have also been associated with elevation of plasma aldosterone
concentration in patients with essential hypertension.
Thus, low sodium chloride diet may reduce the measured Blood pressure
but in principle can increase the incidence of atherosclerosis and cardiac
hypertrophy.
Rapid Response:
Low Sodium Chloride Diet may increase chances of atherosclerosis and cardiac hypertrophy
Dear Editor,
According to Harrison's Principles of Internal Medicine, 17th
Edition, volume 2, Page 1552:
In response to low sodium chloride diet, arterial pressure and volume
homeostasis may be maintained by increased activity of renin-angiotensin-
aldosterone axis. However, independent of its hemodynamic effect,
angiotensin II may play a role in the pathogenesis of atherosclerosis
through a direct action on the vessel walls. On the other hand,
independent of its potential effect on blood pressure, aldosterone may
also play role in cardiac hypertrophy. Aldosterone acts via
mineralocorticoid receptor within the myocardium to enhance extracellular
matrix and collegen diposition. Pathologic patterns of left ventricular
geometry have also been associated with elevation of plasma aldosterone
concentration in patients with essential hypertension.
Thus, low sodium chloride diet may reduce the measured Blood pressure
but in principle can increase the incidence of atherosclerosis and cardiac
hypertrophy.
Competing interests: No competing interests