An overloked pathophysiological mechanism of rhabdomyolysis, recognizable clinically.
Sir,
In my opinion, as regards pathophysiological mechanisms underlying
rhabdomyolysis, we have to take into account particularly Co Q10
deficiency syndrome, that can nowadays be recognized in a quantitative
manner at the bed side by means of biophysical semeiotics (1, 2) (See
HONCode site http://digilander.libero.it/semeioticabiofisica). In fact,
among the numerous causes inducing rhabdomyolysis there are statins, which
are moreover of particular concern because of their widespread and
increasing use.
Statins can bring about, to some extent, rhabdomyolysis,
but exclusively in patients affected already by ubidecarenone deficiency,
since these drugs impaire normally also Co Q10 synthesis with subsequent
functional, mitochondrial damage, as I discussed in previous article, as
far as cerivastatine is concerned (3). As a matter of fact, drug
interactions particularly with fibrates or drugs that interfere with
cytochrome p450, the main isoenzyme involved in the metabolism of statins,
seem to account for most instances, but only in individuals with Co Q10
deficiency syndrome, diagnosed clinically, as stated above.
1) Stagnaro-Neri M., Stagnaro S., Sindrome clinica percusso-
ascoltatoria da carenza di Co Q10. Medic. Geriatr. XXIV, 239, 1993.
2) Stagnaro-Neri M., Stagnaro S., Carenza di Co Q10 secondaria a terapia
ipolipidemizante diagnosticata con la Percussione Ascoltata. Settimana
Italiana di Dietologia, 9-13 Aprile 1991, Merano. Atti, pg. 65. Epat. 37,
17, 1990
3) Stagnaro-Neri M., Stagnaro S., La sindrome percusso-ascoltatoria da
carenza di Carnitina. Clin. Ter. 145, 135 [Pub-Med indexed for MEDLINE]
Rapid Response:
An overloked pathophysiological mechanism of rhabdomyolysis, recognizable clinically.
Sir,
In my opinion, as regards pathophysiological mechanisms underlying
rhabdomyolysis, we have to take into account particularly Co Q10
deficiency syndrome, that can nowadays be recognized in a quantitative
manner at the bed side by means of biophysical semeiotics (1, 2) (See
HONCode site http://digilander.libero.it/semeioticabiofisica). In fact,
among the numerous causes inducing rhabdomyolysis there are statins, which
are moreover of particular concern because of their widespread and
increasing use.
Statins can bring about, to some extent, rhabdomyolysis,
but exclusively in patients affected already by ubidecarenone deficiency,
since these drugs impaire normally also Co Q10 synthesis with subsequent
functional, mitochondrial damage, as I discussed in previous article, as
far as cerivastatine is concerned (3). As a matter of fact, drug
interactions particularly with fibrates or drugs that interfere with
cytochrome p450, the main isoenzyme involved in the metabolism of statins,
seem to account for most instances, but only in individuals with Co Q10
deficiency syndrome, diagnosed clinically, as stated above.
1) Stagnaro-Neri M., Stagnaro S., Sindrome clinica percusso-
ascoltatoria da carenza di Co Q10. Medic. Geriatr. XXIV, 239, 1993.
2) Stagnaro-Neri M., Stagnaro S., Carenza di Co Q10 secondaria a terapia
ipolipidemizante diagnosticata con la Percussione Ascoltata. Settimana
Italiana di Dietologia, 9-13 Aprile 1991, Merano. Atti, pg. 65. Epat. 37,
17, 1990
3) Stagnaro-Neri M., Stagnaro S., La sindrome percusso-ascoltatoria da
carenza di Carnitina. Clin. Ter. 145, 135 [Pub-Med indexed for MEDLINE]
4) Stagnaro Sergio Statine e Cerivastatina. www.piazzetta.sfera.net.
URL:
http://digilander.libero.it/piazzettamedici/professione/professione.htm
Competing interests:
None declared
Competing interests: No competing interests