Quality of diet and mortality among Japanese men and women: Japan Public Health Center based prospective studyBMJ 2016; 352 doi: http://dx.doi.org/10.1136/bmj.i1209 (Published 22 March 2016) Cite this as: BMJ 2016;352:i1209
- Kayo Kurotani, senior researcher1,
- Shamima Akter, researcher1,
- Ikuko Kashino, researcher1,
- Atsushi Goto, assistant professor2,
- Tetsuya Mizoue, director1,
- Mitsuhiko Noda, director, professor34,
- Shizuka Sasazuki, division chief5,
- Norie Sawada, section chief5,
- Shoichiro Tsugane, director of Research Centre for Cancer Prevention and Screening5,
- Japan Public Health Center based Prospective Study Group
- 1Department of Epidemiology and Prevention, Centre for Clinical Sciences, National Centre for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, Japan, 162-8655
- 2Department of Public Health, Tokyo Women’s Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo, Japan, 162-8666
- 3Department of Diabetes Research, National Centre for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, Japan, 162-8655
- 4Department of Endocrinology and Diabetes, Saitama Medical University, 38 Moro-hongo, Moroyama, Iruma-gun, Saitama, Japan, 350-0495
- 5Epidemiology and Prevention Group, Research Centre for Cancer Prevention and Screening, National Cancer Centre, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan, 104-0045
- Correspondence to: K Kurotani
- Accepted 12 February 2016
Objective To examine the association between adherence to the Japanese Food Guide Spinning Top and total and cause specific mortality.
Design Large scale population based prospective cohort study in Japan with follow-up for a median of 15 years.
Setting 11 public health centre areas across Japan.
Participants 36 624 men and 42 970 women aged 45-75 who had no history of cancer, stroke, ischaemic heart disease, or chronic liver disease.
Main outcome measures Deaths and causes of death identified with the residential registry and death certificates.
Results Higher scores on the food guide (better adherence) were associated with lower total mortality; the multivariable adjusted hazard ratios (95% confidence interval) of total mortality for the lowest through highest scores were 1.00, 0.92 (0.87 to 0.97), 0.88 (0.83 to 0.93), and 0.85 (0.79 to 0.91) (P<0.001 for trend) and the multivariable adjusted hazard ratio associated with a 10 point increase in food guide scores was 0.93 (0.91 to 0.95; P<0.001 for trend). This score was inversely associated with mortality from cardiovascular disease (hazard ratio associated with a 10 point increase 0.93, 0.89 to 0.98; P=0.005 for trend) and particularly from cerebrovascular disease (0.89, 0.82 to 0.95; P=0.002 for trend). There was some evidence, though not significant, of an inverse association for cancer mortality (0.96, 0.93 to 1.00; P=0.053 for trend).
Conclusion Closer adherence to Japanese dietary guidelines was associated with a lower risk of total mortality and mortality from cardiovascular disease, particularly from cerebrovascular disease, in Japanese adults.
Life expectancy of the Japanese population has steadily increased over the past few decades and is currently among the longest in the world, with Japanese women recording the longest life expectancy of 87 in 2012.1 Various factors, including socioeconomic and cultural background, as well as universal coverage of health insurance, have jointly contributed to the improvement of health among the Japanese population.2 Of these, special attention has been paid to the role of the Japanese diet, which has been improved in terms of nutritional balance during economic development3 4 while maintaining the traditional dietary culture (for instance, high intake of fish and soybean products and low intake of fat).5 Thus, the association between the diet of the Japanese population and risk mortality is of substantial clinical interest.
The assessment of overall diet quality has been shown to be useful in evaluating the effect of diet on morbidity or mortality.6 More than 25 a priori defined dietary scoring systems have been developed to assess diet quality based on adherence to dietary recommendations or guidelines specific to the country where the tool was developed.6 For example, the healthy eating index7 and the alternate healthy eating index8 were developed in the United States according to Dietary Guidelines for Americans on the basis of nutrient and food intake. In Japan, the Ministry of Health, Labour and Welfare and the Ministry of Agriculture, Forestry and Fisheries of Japan jointly developed the Japanese Food Guide Spinning Top in 2005 (fig 1⇓).9 This guide attempts to illustrate the balance and quantity of food in the daily Japanese diet.9 In 2009, Oba and colleagues developed a scoring system to measure the adherence to the food guide based on intake of grain dishes, vegetable dishes, fish and meat dishes, milk, and fruits, as well as the total daily energy and energy from snacks and alcoholic beverages.10
Higher diet quality scores have been consistently associated with a lower risk of mortality.10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 All cause mortality was reportedly reduced by 11-42%,10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 cardiovascular disease mortality by 17-60%,10 11 14 15 16 18 19 20 22 23 24 and cancer mortality by 11-40%11 14 15 16 18 19 23 in individuals with the highest category of scores of diet quality compared with individuals with the lowest category. To the best of our knowledge, only two Asian studies have previously examined the association between diet quality and mortality. These studies showed an association between adherence to the Japanese Food Guide Spinning Top and the Chinese Food Pagoda and lower risk of mortality in each of the respective populations.10 19 As the Japanese study was conducted in a single city,10 the results obtained might not be generalisable to the entire Japanese population. Additionally, several dietary scoring systems have been developed for the assessment of fish and meat separately or the quality of fat,6 which are potentially important for prevention of cardiovascular disease.26 The Japanese food guide score, however, does not distinguish between fish and meat.10 The incorporation of such a component into the original score could improve its prediction of mortality. We prospectively examined the associations between the standard and modified scores on the Japanese Food Guide Spinning Top and total and cause specific mortality using data from a large scale population based cohort study in Japan.
The Japan Public Health Center based prospective (JPHC) study was launched in 1990 for cohort I and in 1993 for cohort II.27 The participants of cohort I included residents aged 40-59 from five Japanese public health centre areas (Iwate, Akita, Nagano, Okinawa-Chubu, and Tokyo). The participants of cohort II included residents aged 40-69 from six public health centre areas (Ibaraki, Niigata, Kochi, Nagasaki, Okinawa-Miyako, and Osaka). A self administrated questionnaire survey was conducted at baseline and at the five and 10 year follow-ups. Information on medical histories and health related lifestyles including smoking, drinking, and dietary habits was obtained at each survey. Because the questionnaire that was used for the five year follow-up survey (that is, the second survey) provided more comprehensive information about food intake than the questionnaire that was used for the baseline survey, we used the second survey data as the baseline data for this analysis.
Food frequency questionnaire
The second survey included data on 147 food and beverage items and nine frequency categories.28 For most food items, nine options were available for describing consumption frequency, ranging from rarely (less than once a month) to seven or more times a day. Regarding food intake, a standard portion size was specified for each food item and the respondents were asked to assess their usual portion size relative to the standard specified for each food item using three options (less than half, standard, and more than one and half times). Daily intake of most foods was calculated by multiplying the daily consumption frequency and the standard portion size by the individual’s usual portion size. From the food frequency questionnaire, we estimated total daily energy intake and intake of each nutrient and food item according to the Japanese standard tables of food composition.29 The food frequency questionnaire has reasonable validity and reproducibility.30 31 32 As regards validity, the Spearman rank correlation coefficients for energy adjusted intakes of food groups between diet records and the food frequency questionnaire ranged from 0.08 for algae to 0.76 for alcoholic beverages in men and 0.06 for algae to 0.66 for milk and dairy products in women in cohort I32 and from 0.11 for algae to 0.69 for milk and dairy products in men and 0.12 for fungi to 0.65 for pickled vegetables in women in cohort II.30 As regard reproducibility, the Spearman rank correlation coefficients for energy adjusted intakes of food groups measured at 12 month intervals with the food frequency questionnaire ranged from 0.38 for total beverages to 0.71 for alcoholic beverages in men and 0.30 for nuts and seeds to 0.74 for milk and dairy products in women in cohort I31 and from 0.38 for algae to 0.70 for alcoholic beverages in men and 0.40 for fish and shellfish and algae to 0.80 for alcoholic beverages in women in cohort II.30
Standard and modified scores on Japanese food guide
We created a score for adherence to a Japanese food guide, with a higher score indicating closer adherence and thus better diet. The Japanese Food Guide Spinning Top is based on the Dietary Guidelines for Japanese, released in 2000, and guides people as to the types and amounts of food they should eat each day to promote health. The food guide comprises five categories of dish: grain dishes (including rice, bread, and noodles), vegetable dishes (including vegetables, mushrooms, potatoes, and seaweed), fish and meat dishes (including meat, fish, eggs, and soybeans, milk (milk and milk products), and fruits (fruit and 100% fruit juice) (fig 1⇑).9 Soybeans are included in category of fish and meat dishes on the basis of nutrient profile (high protein). In the food guide, the amount of food that counts as one serving is defined for each category. One serving of a grain dish is composed of about 40 g carbohydrates. In one serving of a vegetable dish, the main ingredient weighs about 70 g. One serving of fish and meat dish contains about 6 g protein, and one serving of milk contains about 100 mg calcium. In one serving of fruits, the main ingredient weighs about 100 g. The recommended amount of servings for each category and the recommended total energy intake are specified according to sex, age, and level of physical activity, whereas the recommended amount of energy intake from snacks and alcoholic beverages is less than 200 kcal/day for everyone (table 1⇓).
We determined the scores by measuring adherence to the food guide from information in the food frequency questionnaire. First, we calculated the number of servings according to the food guide criteria. Grain dishes included rice, vitamin enriched rice, rice with cereal, bread, Japanese wheat noodles, buckwheat noodles, Okinawa noodles, Chinese noodles, and rice cakes. Vegetable dishes included carrots, spinach, pumpkins, cabbage, Chinese cabbage, Chinese radishes, salted pickles of Chinese radishes, salted pickles of green leafy vegetables, pickled plums, pickled Chinese cabbage, pickled cucumbers, pickled eggplant, sweet pepper, tomatoes, Chinese chives, garland chrysanthemums, komatsuna, broccoli, onions, cucumbers, bean sprouts, snap beans, lettuce, pak choy, leaf mustard, bitter gourds, leaf beet, loofah, mugwort, sweet potato, potato, taro, shiitake mushroom, hackberry, wakame seaweed, dark edible seaweed, lavers, peanuts, and tomato juice. Fish and meat dishes included steak, grilled and stewed beef, stir fried pork, deep fried pork, Western style stewed pork, Japanese style stewed pork, pork in soup, pork liver, ham, sausage or Wiener sausage, bacon and luncheon meats, chicken liver, grilled chicken, deep fried chicken, egg, salmon, skipjack/tuna, cod/flatfish, sea bream, horse mackerel/sardines, saury/mackerel, eel, squid, octopus, shrimp, clams, pond snails, salted fish, dried fish, dried whitebait, salted fish roe, canned tuna, fish paste products (chikuwa and kamaboko), tofu, boiled tofu, fluffy tofu, freeze dried tofu, deep fried tofu, fermented soybean (natto), and soymilk (tofu and soy products are included in this category because of their nutrient profile). Milk included cows’ milk, cheese, yoghurt, Japanese probiotic milk drink, and milk in tea and coffee. Fruits included papaya, mandarin oranges, other oranges, apples, persimmons, strawberries, grapes, melons, watermelon, peaches, pears, kiwifruit, pineapple, bananas, 100% orange juice, and 100% apple juice. Snacks and alcoholic beverages included Japanese rice wine (sake), shochu, beer, whisky, wine, Japanese confectionaries, cake, biscuits, chocolate, canned coffee, coke, and sugar in tea and coffee.
Table 2⇓ shows the procedure of creating an adherence score for the food guide. We classified participants who engaged in manual labour or walked at least one hour a day as moderately physically active and the remaining as sedentary. For vegetable dishes and fruits, we modified the original criteria (recommended range) to remove the upper limit of intake, conforming to other scoring systems.16 21 For example, the food guide recommends five to six servings of vegetable dishes for men aged ≥70, but we modified this to five or more servings. If individuals consumed the recommended amount of servings from any of the five categories or the recommended total energy or energy from snacks and alcoholic beverages, 10 points were given for that group. If individuals exceeded or fell short of the recommended servings or energy, the score was calculated proportionately between 0 and 10. If an individual consumed less than the recommended amount of servings or energy, the score was calculated with the following formula: 10×(the consumed amount of servings or energy)/(the lower limit of the recommended amount). If an individual consumed more than the recommended amount of servings or energy, the score was calculated with the following formula: 10−10×[(the consumed amount of servings or energy)−(the upper limit of the recommended amount)]/(the upper limit of the recommended amount). Each score was rounded off to the nearest whole number. When this calculation produced a negative score because of excess servings or energy, the score was converted to 0. All group scores were summed to obtain a total score ranging from 0 (the lowest adherence) to 70 (the highest adherence). We added the ratio of white to red meat as a new component to the score, creating the modified score according to the alternate healthy eating index.8 White meat was defined as grilled chicken, deep fried chicken, salmon, skipjack/tuna, cod/flatfish, sea bream, horse mackerel/sardine, saury/mackerel, eel, squid, octopus, shrimp, clam, pond snails, salted fish, dried fish, dried whitebait, salted fish roe, canned tuna, and fish paste products. Red meat was defined as steak, grilled and stewed beef, stir fried pork, deep fried pork, Western style stewed pork, Japanese style stewed pork, pork in soup, pork liver, ham, sausage or Wiener sausage, bacon and luncheon meats, and chicken liver. Gram quantities were summed and used to calculate the ratio. An ideal score of 10 was given for ratios ≥4:1,8 whereas a score of 0 was given for a ratio of 0. Intermediate intakes were scored proportionately between 0 and 10. The food guide score and the ratio of white to red meat score were summed to obtain a modified score ranging from 0 (worst) to 80 (best) (table 2⇓).
Of the potential participants at baseline (n=140 420), 103 450 responded to the second survey; of these, 102 364 completed the food frequency questionnaire at the second survey. Of these participants, we excluded 10 227 because of missing information regarding the number of bowls of rice consumed and the frequency of intake of the following: more than half of the vegetable items, more than half of the fish and meat dishes items, milk, more than half of the fruit items, all snack items, and alcoholic beverage items. Of 92 137 participants, we excluded 6215 who reported consumption in the upper 1% of sex specific intakes of each category (grain dishes, vegetable dishes, fish and meat dishes, milk, fruits, as well as energy from snacks and alcohol) or in either the upper or lower 1% of sex specific energy intake. We also excluded 6328 participants who reported history of cancer, stroke, ischaemic heart disease, or chronic liver disease in the baseline and second survey. Ultimately, 79 594 participants (36 624 men and 42 970 women) remained for the present analysis.
Reproducibility of dietary intake
Of the participants in the analytic cohort, 43 676 (19 778 men and 23 898 women) participated in the 10 year follow-up survey (that is, the third survey) and completed the food frequency questionnaire. Dietary intake between the second and the third surveys was moderately stable. The Spearman rank correlation coefficients for each intake between the two surveys were as follows: 0.47 and 0.45 for grain dishes, 0.52 and 0.55 for vegetable dishes, 0.46 and 0.50 for fish and meat dishes, 0.52 and 0.51 for milk, 0.54 and 0.56 for fruits, 0.49 and 0.51 for total energy, 0.52 and 0.50 for energy from snacks, and 0.64 and 0.64 for alcohol in men and women, respectively. The score on the food guide between two surveys was also moderately stable. The Spearman rank correlation coefficient of the score was 0.50 in men and 0.45 in women.
Follow-up and outcome
We followed up the participants’ residency and vital status from the second survey to 31 December 2012 using the residential registry. Causes of deaths were confirmed through death certificates (with permission) and were defined according to ICD-10 (international classification of diseases, 10th revision).33 The major endpoint of the present study was mortality from all causes, cancer (ICD-10 codes C00 to C97), cardiovascular disease (I00 to I99), heart disease (I20 to I52), and cerebrovascular disease (I60 to I69).
We calculated person years of follow-up for each person starting from the date of response to the second survey questionnaire until the date of death, emigration from Japan, or 31 December 2012, whichever came first. For individuals who were lost to follow-up, we used the last confirmed date of their participation in the study area as the censoring date. Participants were divided into fourths of food guide scores. We considered the following confounding variables collected at the second survey: age (years, continuous), sex, study area (11 areas), body mass index (BMI <21, 21.0-22.9, 23.0-24.9, 25.0-26.9, or ≥27.0), smoking status (lifetime non-smoker, former smoker, or current smoker with a consumption of either <20 or ≥20 cigarettes/day), total physical activity (metabolic equivalent task h/day, fourths), a history of diabetes mellitus (yes or no), a history of hypertension (yes or no), a history of dyslipidaemia (yes or no), coffee consumption (almost never, <1, 1, or ≥2 cups/day; 1 cup=120 mL), green tea consumption (almost never, <1, 1, 2-3, or ≥4 cups/day), and occupation (agriculture/forestry/fishery, salaried/professional, self employed, multiple occupations, housework/unemployed, or other). For participants with missing data on BMI, smoking status, physical activity, coffee consumption, green tea consumption, or occupation, we imputed the data using multivariate normal imputation (the SAS PROC MI procedure) with five rounds of multiple imputations by including all covariates, follow-up length, and mortality status to account for missing data. We then combined the estimates from each imputed dataset using Rubin’s rules (the SAS PROC MIANALYZE procedure).34 We used Cox proportional hazards regression analysis to estimate hazard ratios and 95% confidence intervals of mortality from total and cause specific mortality for fourths of the food guide scores and the modified scores, using the lowest fourth as a reference. The first model was adjusted for age, sex, and study area, and the second model was further adjusted for BMI, smoking status, total physical activity, history of diabetes mellitus, history of hypertension, history of dyslipidaemia, coffee consumption, green tea consumption, and occupation. We estimated hazard ratios and the corresponding 95% confidence intervals for a 10 point increase in the standard and modified scores. The linear trend was computed by treating exposure as a continuous variable. We confirmed that the quadratic term of the score added to the multivariable adjusted model was not significantly associated with any outcome. In addition, to visually inspect possible non-linear associations, we used restricted cubic spline with five knots placed at the 5th, 25th, 50th, 75th, and 95th centiles of the food guide score. The reference value for estimating hazard ratios and 95% confidence intervals was chosen as 8, the lowest value of this score.
We estimated hazard ratios and the corresponding 95% confidence intervals for mortality from total and cause specific mortality for a 1 point increment in the score for each dish category. To estimate the impact of each component of the score on the association between the total dietary score and mortality, we calculated the proportion of hazard ratio attenuation in the highest fourth with the following formula: (hazard ratio adjusted for all covariates plus each dish score−hazard ratio adjusted for all covariates [not including dish score])/(1−hazard ratio adjusted for all covariates [not including dish score])×100.
Data were analysed stratified by sex, BMI (<25 or ≥25), smoking status (men only), and menopausal status. By multiplying the score (continuous) and the above stratifying variables (dichotomous), we created an interaction term that we added to the model to assess statistical interactions. We conducted multiple sensitivity analyses by excluding individuals with a history of diabetes mellitus, hypertension, or dyslipidaemia and those who died during the first three years of follow-up. The proportional hazards assumption was tested by including a product term between fourths of the score and the follow-up period in the models; no significant violation of the assumption was found (all P>0.10). All analyses were performed with SAS version 9.3 for Windows (SAS Institute, Cary, NC) and Stata version 13.1 (StataCorp, College Station, TX).
No patients were involved in setting the research question or the outcome measures, nor were they involved in the design and implementation of the study. There are no plans to involve patients in dissemination.
At baseline (the time of the second survey), the mean standard and modified scores on the Japanese Food Guide Spinning Top were 47.4 (SD 10.2) and 53.0 (SD 11.0), respectively. Scores can range from 0 to 70 (modified 0-80), with higher scores indicating better adherence and therefore a better diet. Compared with individuals with a lower dietary score, individuals with a higher score were older and more likely to be women, be engaged in primary industry, have a history of dyslipidaemia, drink green tea, and have a higher energy intake but were less likely to be a current smoker, drink alcohol every week, or have a history of hypertension (table 3⇓).
During the mean follow-up time of 14.9 (SD 3.3) years, the numbers of deaths from all causes, cancer, cardiovascular disease, heart disease, and cerebrovascular disease were 10 183, 4187, 2560, 1342, and 1005, respectively. After adjustment for potential confounding variables, higher food guide scores were found to be associated with lower total mortality; multivariable adjusted hazard ratios (95% confidence intervals) of total mortality for the lowest through highest fourth scores were 1.00, 0.92 (0.87 to 0.97), 0.88 (0.83 to 0.93), and 0.85 (0.79 to 0.91) (P<0.001 for trend; table 4⇓). The multivariable adjusted hazard ratio of total mortality for a 10 point increment in the score was 0.93 (0.91 to 0.95).
For cause specific mortality, cardiovascular disease mortality (particularly cerebrovascular disease mortality) was inversely associated with the food guide score; the multivariable adjusted hazard ratios (95% confidence intervals) of cardiovascular disease mortality for the lowest through highest fourth category of scores were 1.00, 0.97 (0.87 to 1.07), 0.86 (0.77 to 0.97), and 0.84 (0.73 to 0.96) (P=0.005 for trend). The corresponding values for cerebrovascular disease mortality were 1.00, 0.97 (0.82 to 1.15), 0.81 (0.68 to 0.98), and 0.78 (0.63 to 0.97) (P=0.002). The multivariable adjusted hazard ratio (95% confidence interval) of cardiovascular disease and cerebrovascular disease mortality for a 10 point increment in the food guide score were 0.93 (0.89 to 0.98) and 0.89 (0.82 to 0.95), respectively. There was some evidence (though not quite significant) of an inverse association between the score and cancer mortality (hazard ratio for a 10 point increment in the dietary score 0.96, 0.93 to 1.00; P=0.053). These associations appeared to be linear (fig C and E, appendix 1). Mortality from heart disease was not associated with the score.
Higher modified food guide scores were associated with a lower risk of total, cardiovascular disease, and cerebrovascular disease mortality (table 5⇓); the multivariable adjusted hazard ratios (95% confidence intervals) of total, cardiovascular disease, and cerebrovascular disease mortality for the highest versus lowest fourth of the dietary score were 0.82 (0.77 to 0.88; P<0.001 for trend), 0.81 (0.71 to 0.93; P=0.001 for trend), and 0.77 (0.62 to 0.96; P=0.001 for trend), respectively. The modified score was inversely associated with cancer mortality, although the association did not reach significance (P=0.06 for trend).
Regarding components of the food guide score, scores for vegetable dishes, fish and meat dishes, milk, fruits, and total energy were inversely associated with total mortality (table A, appendix 2). Lower mortality was observed for cardiovascular disease among those with a higher score for vegetable dishes or fruits, for cerebrovascular disease among those with a higher score for fish and meat dishes or fruits, and for heart disease among those with a higher milk score.
We observed relatively large attenuation in associations with the food guide score (≥20%) after additional adjustment for the fruit score (29.3%) and vegetable dishes score (29.2%) for total mortality, fruit score (23.5%), and vegetable dishes score (20.6%) for cardiovascular disease mortality, and fish and meat dishes score (23.0%) and fruit score (22.8%) for cerebrovascular disease mortality (data not shown in table).
In sensitivity analyses, the observed associations did not change after we excluded total deaths during the first three years of follow-up (n=1031). Exclusion of individuals with a history of diabetes, hypertension, or dyslipidaemia (n=20 080) strengthened the observed associations with total, cardiovascular disease, and cerebrovascular disease mortalities; the multivariable adjusted hazard ratios (95% confidence interval) of total, cardiovascular disease, and cerebrovascular disease mortalities for the highest fourth of food guide scores compared with the lowest were 0.82 (0.75 to 0.89), 0.76 (0.63 to 0.91), and 0.61 (0.46 to 0.83), respectively, and for the modified score were 0.80 (0.73 to 0.87), 0.74 (0.61 to 0.89), and 0.62 (0.46 to 0.83), respectively (all P<0.001 for trend).
In stratified analyses (table B, appendix 2), we observed an inverse association between the score on the food guide for total mortality in individuals with normal weight (P<0.001 for trend) but not in overweight/obese individuals (P=0.53 for trend), and more pronounced in men who smoked (P<0.001 for trend) than in those who did not (P=0.03 for trend); the differences in these subgroup effects were also significant (P<0.001 for interaction with BMI and P=0.03 for interaction with smoking). There was no significant difference in association with total mortality according to sex and menopausal status.
We observed a significant inverse trend for cancer mortality in men (P=0.02 for trend) but not in women (P=0.96 for trend); there was, however, no significant evidence of a difference in these effects between men and women (P=0.11 for interaction by sex). There was a significant effect in individuals with normal weight (P=0.02 for trend) but not in overweight/obese individuals (P=0.79 for trend); the difference in these subgroup effects was also significant (P=0.003 for interaction by BMI). As regards cardiovascular disease mortality, we observed a significant inverse trend in individuals with normal weight (P=0.001 for trend) but not in overweight/obese individuals (P=0.87 for trend); there was, however, no significant evidence of a difference in these subgroup effects (P=0.69 for interaction with BMI). There was a significant inverse association with cardiovascular disease mortality in women (P=0.01 for trend) but not in men (P=0.18 for trend); there was, however, no significant evidence of a difference in these effects between men and women (P=0.08 for interaction by sex). After we excluded those with a history of diabetes, hypertension, or dyslipidaemia at baseline, the association in men became significant (P=0.004 for trend).
In this large prospective cohort in Japan, individuals with higher adherence to the Japanese Food Guide Spinning Top had a 15% lower total mortality rate. This protective association was mainly attributable to a reduction in mortality from cerebrovascular disease. The associations observed with the modified score, with a greater emphasis on fish intake relative to red meat intake, were not significantly different from those with the original score. The present study is one of the few to examine the association between adherence to dietary recommendations or guidelines and mortality in Asian populations.
Findings in relation to other studies
Our findings agree with those from other studies that reported that higher diet quality scores were associated with reduced total mortality.10 11 12 13 14 15 16 17 18 19 20 21 22 23 In China, the Chinese Food Pagoda score assesses the adherence to the Chinese Food Pagoda, which is based on food groups according to the Dietary Guidelines for Chinese.19 The concept of the Chinese Food Pagoda score is similar to that of the Japanese Food Guide Spinning Top. In the Shanghai Men’s Health Study (n=61 239) and the Shanghai Women’s Health Study (n=73 216), the highest fourth of the Chinese Food Pagoda score was associated with a 33% and 13% lower rate of total mortality in men and women, respectively, compared with the lowest fourth.19 In the Iowa Women’s Health Study18 and the Whitehall II cohort,22 the highest category of the alternate healthy eating index, which includes components similar to those of the Japanese food guide, predicted 18% and 25% lower rate of total mortality, respectively. In the Multiethnic Cohort,23 the highest diet quality score, including the healthy eating index-2010 and the alternate healthy eating index-2010, was associated with 22-25% and 21-22% lower rate of total mortality in men and women, respectively. This epidemiological evidence, including the present findings, suggests that individuals with higher adherence to country specific dietary recommendations have a lower risk of total mortality.
We found that a higher score on the Japanese Food Guide Spinning Top was associated with a lower rate of total mortality over 15 years of follow-up in both men and women. The score we used in this study was based on the score developed by Oba and colleagues, who found no clear association between the scores and risk of total mortality over seven years of follow-up among men from Japan and a significant inverse association among women.10 We have no clear explanation for the observed difference in men between our study and the previous one,10 but it might be attributable to the different scoring of vegetable dishes and fruits used in each study. When individuals consumed more than the recommended equivalents of vegetable dishes or fruits, their scores for these foods were deducted in the previous Japanese study. In contrast, we assigned the highest score (10 points) to individuals who consumed more than the recommended amounts of vegetable dishes or fruits. Given that higher intake of vegetables and fruits has been associated with a lower risk of mortality,35 the previous study10 might have underestimated this association.
In most studies, higher diet quality scores have been consistently and strongly associated with reduced mortality from cardiovascular disease.11 18 19 20 22 23 36 In our study, individuals in the highest fourth of the food guide scores had a 16% lower rate of mortality from cardiovascular disease compared with those in the lowest fourth. This association was partly explained by intake of vegetable dishes and fruits, which have been linked to a lower risk of cardiovascular disease not only in the present study37 but also in numerous other studies.35 Likewise, the association with mortality from cerebrovascular disease was partly explained by intake of fish and meat dishes. A meta-analysis of 18 prospective studies showed a lower risk of cerebrovascular disease associated with high consumption of fish.38 A prospective study in Shanghai showed that higher intake of red meat is associated with a lower risk of mortality from haemorrhagic stroke.39 Our findings, together with previous reports, suggest that a dietary pattern of high intake of vegetables and fruits and adequate intake of fish and meat can significantly decrease the risk of mortality from cardiovascular disease in East Asian populations, particularly from cerebrovascular disease.40
We found a less clear association between score on the Japanese Food Guide Spinning Top and mortality from cancer in the whole study population, corroborating results of previous studies.10 11 14 15 16 18 19 20 22 23 25 This could reflect the fact that cancer is a heterogeneous endpoint and that diet is involved in the pathogenesis of certain cancers.41 In subgroup analyses, we found a significantly decreasing trend of mortality from cancer with closer adherence to the food guide in men but not in women. This could be due to chance, especially as there was no significant evidence of a difference between men and women. If the finding was genuine, however, it might potentially be explained by sex difference of major forms of cancer, on which diet has differential impact. Specifically, vegetables and/or fruits probably protect against cancers of the lung, stomach, oesophagus, mouth, pharynx, and larynx and milk probably protects against colorectal cancer, whereas there is convincing evidence that red meat and processed meat increase the risk of colorectal cancer.42 Of all deaths from cancer in the present cohort, the proportions of deaths from the above mentioned cancers were much higher in men (60.6%) than in women (40.4%). We observed a significant inverse association between the diet score and mortality from cancer in individuals with normal weight but not in overweight/obese individuals. There was also significant evidence of a difference in effects between normal and overweight/obese groups. Further investigation is required to identify specific groups of individuals who benefit from following the Japanese food guidelines in prevention of cancer.
One concern is that the score on the Japanese Food Guide Spinning Top does not consider the quality of fat, which might have a primary impact on risk of cardiovascular disease, as indicated by a recent randomised controlled trial.26 Fish, the major (92%) component of category of white meat in the present study population, is rich in n-3 polyunsaturated fatty acids, whereas red meat, including beef and pork, contains saturated fatty acids.43 We developed a modified score by adding the score for the ratio of intake of white to red meat but found no measurable difference in the association between the two scores. This finding could be explained by the higher consumption of fish44 45 and lower consumption of beef and pork45 46 among the Japanese population compared with Western populations, maintaining an appropriate balance between white and red meat intakes in terms of cardiovascular health. In our study, a higher intake of fish and n-3 polyunsaturated fatty acids was associated with a decreased risk of myocardial infarction,47 and a higher intake of saturated fatty acids was associated with a decreased risk of stroke.48
Strengths and limitations
The strengths of the present study were its population based prospective design involving a large cohort, the long duration of follow-up (15 years), and the use of a validated food frequency questionnaire. Our study also has several limitations. Firstly, the food frequency questionnaire was not developed for the purpose of estimating the adherence to the Japanese Food Guide Spinning Top. However, we used 125 of 147 (85%) food and beverage items in the validated food frequency questionnaire, and we retrospectively calculated dish servings according to the food guide. Thus, well designed food frequency questionnaires could be used to estimate dish servings and calculate the adherence score. Secondly, dietary intake was assessed only at baseline and might not represent long term habitual intake relevant to mortality. In the present cohort, however, dietary intake was generally stable over time; the Spearman rank correlation coefficients of intake of each dish category between the second and the third surveys ranged between 0.46 and 0.64 in men and between 0.45 and 0.64 in women. Thirdly, our analysis included individuals with a history of diabetes, hypertension, or dyslipidaemia, who might have received advice to follow the dietary guidelines for each disease and changed their diet accordingly. In sensitivity analyses, the associations between the dietary score and mortality were strengthened after we excluded these individuals. Finally, we cannot completely rule out the effects of confounding by residual and unmeasured variables. One such example is smoking, which is a strong predictor of mortality49 and is associated with dietary habits. In stratified analysis, we found more pronounced inverse associations between dietary scores and mortality in men who smoked; however, this observation might also be a result of incomplete control of smoking intensity. Furthermore, the observed associations were materially unchanged after adjustment for the number of cigarettes smoked, suggesting that smoking intensity is unlikely to have contributed to residual confounding in the present study.
In summary, individuals with closer adherence to the Japanese dietary guidelines had a lower risk of death from all causes and cardiovascular disease, particularly cerebrovascular disease. Our findings suggest that balanced consumption of energy, grains, vegetables, fruits, meat, fish, eggs, soy products, dairy products, confectionaries, and alcoholic beverages can contribute to longevity by decreasing the risk of death, predominantly from cardiovascular disease, in the Japanese population.
What is already known on this topic
Studies in Western populations have shown that better quality of diet is associated with lower mortality from major chronic diseases
The evidence on this issue from prospective studies is scarce among Asian populations
What this study adds
Closer adherence to Japanese dietary guidelines was associated with a lower risk of death from all causes and cardiovascular disease, particularly cerebrovascular disease
Balanced consumption of various dishes might contribute to longevity in the Japanese population
We are indebted to the Aomori, Iwate, Ibaraki, Niigata, Osaka, Kochi, Nagasaki, and Okinawa Cancer Registries for providing their incidence data.
Members of the Japan Public Health Center based Prospective (JPHC) Study Group
S Tsugane (principal investigator), N Sawada, M Iwasaki, S Sasazuki, T Yamaji, T Shimazu, T Hanaoka, National Cancer Centre, Tokyo; J Ogata, S Baba, T Mannami, A Okayama, Y Kokubo, National Cerebral and Cardiovascular Centre, Osaka; K Miyakawa, F Saito, A Koizumi, Y Sano, I Hashimoto, T Ikuta, Y Tanaba, H Sato, Y Roppongi, T Takashima, H Suzuki, Iwate Prefectural Ninohe Public Health Centre, Iwate; Y Miyajima, N Suzuki, S Nagasawa, Y Furusugi, N Nagai, Y Ito, S Komatsu, T Minamizono, Akita Prefectural Yokote Public Health Centre, Akita; H Sanada, Y Hatayama, F Kobayashi, H Uchino, Y Shirai, T Kondo, R Sasaki, Y Watanabe, Y Miyagawa, Y Kobayashi, M Machida, K Kobayashi, M Tsukada, Nagano Prefectural Saku Public Health Centre, Nagano; Y Kishimoto, E Takara, T Fukuyama, M Kinjo, M Irei, H Sakiyama, Okinawa Prefectural Chubu Public Health Centre, Okinawa; K Imoto, H Yazawa, T Seo, A Seiko, F Ito, F Shoji, R Saito, Katsushika Public Health Centre, Tokyo; A Murata, K Minato, K Motegi, T Fujieda, S Yamato, Ibaraki Prefectural Mito Public Health Centre, Ibaraki; K Matsui, T Abe, M Katagiri, M Suzuki, K Matsui, Niigata Prefectural Kashiwazaki and Nagaoka Public Health Centre, Niigata; M Doi, A Terao, Y Ishikawa, T Tagami, Kochi Prefectural Chuo-higashi Public Health Centre, Kochi; H Sueta, H Doi, M Urata, N Okamoto, F Ide, H Goto, R Fujita, Nagasaki Prefectural Kamigoto Public Health Center, Nagasaki; H Sakiyama, N Onga, H Takaesu, M Uehara, T Nakasone, M Yamakawa, Okinawa Prefectural Miyako Public Health Centre, Okinawa; F Horii, I Asano, H Yamaguchi, K Aoki, S Maruyama, M Ichii, M Takano, Osaka Prefectural Suita Public Health Centre, Osaka; Y Tsubono, Tohoku University, Miyagi; K Suzuki, Research Institute for Brain and Blood Vessels Akita, Akita; Y Honda, K Yamagishi, S Sakurai, N Tsuchiya, University of Tsukuba, Ibaraki; M Kabuto, National Institute for Environmental Studies, Ibaraki; M Yamaguchi, Y Matsumura, S Sasaki, S Watanabe, National Institute of Health and Nutrition, Tokyo; M Akabane, Tokyo University of Agriculture, Tokyo; T Kadowaki, M Inoue, University of Tokyo, Tokyo, M Noda, T Mizoue, National Centre for Global Health and Medicine, Tokyo; Y Kawaguchi, Tokyo Medical and Dental University, Tokyo; Y Takashima, Y Yoshida, Kyorin University, Tokyo; K Nakamura, R Takachi, Niigata University, Niigata; J Ishihara, Sagami Women’s University, Kanagawa; S Matsushima, S Natsukawa, Saku General Hospital, Nagano; H Shimizu, Sakihae Institute, Gifu; H Sugimura, Hamamatsu University School of Medicine, Shizuoka; S Tominaga, Aichi Cancer Centre, Aichi; N Hamajima, Nagoya University, Aichi; H Iso, T Sobue, Osaka University, Osaka; M Iida, W Ajiki, A Ioka, Osaka Medical Centre for Cancer and Cardiovascular Disease, Osaka; S Sato, Chiba Prefectural Institute of Public Health, Chiba; E Maruyama, Kobe University, Hyogo; M Konishi, K Okada, I Saito, Ehime University, Ehime; N Yasuda, Kochi University, Kochi; S Kono, Kyushu University, Fukuoka; S Akiba, Kagoshima University, Kagoshima; T Isobe, Keio University, Tokyo; Y Sato, Tokyo Gakugei University, Tokyo.
Contributors: ST was involved in the design of study as the principal investigator; ST, NS, and SS conducted the survey; KK, SA, IK, AG, TM, and MN drafted the plan for the data analyses; KK, SA, and AG conducted data analysis; AG and TM provided statistical expertise; KK drafted the manuscript; KK and TM had primary responsibility for final content; and all authors were involved in interpretation of the results and revision of the manuscript and approved the final version of the manuscripts. KK and TM are guarantors.
Funding: This study was supported by National Cancer Centre research and development fund (23-A-31[toku] and 26-A-2) (since 2011), a grant-in-aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan (from 1989 to 2010), Practical Research Project for Life-Style related Diseases including Cardiovascular Diseases and Diabetes Mellitus (15ek0210021h0002) from the Japan Agency for Medical Research and Development, JSPS KAKENHI Grant No 15H04779, and grants-in-aid for research from the National Centre for Global Health and Medicine (26A-201).
Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare: no support from any organisation for the submitted work; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work.
Ethical approval: This study was approved by the institutional review board of the National Cancer Centre of Japan and the ethics committee of the National Centre for Global Health and Medicine, Japan. Although we did not require written informed consent, the study participants were informed of the objectives of the study; participants who responded to the questionnaire survey were considered to have consented to participating in the survey.
Transparency: KK and TM affirm that the manuscript is an honest, accurate, and transparent account of the study being reported; that no important aspects of the study have been omitted; and that any discrepancies from the study as planned have been explained.
Data sharing: No additional data available.
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