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  1. Clinical Review

    Sepsis associated acute kidney injury

    Jason T Poston, Jay L Koyner
    (Published 09 January 2019)

    University of Chicago Correspondence to: J L Koyner jkoyner{at} ABSTRACT Sepsis is ... common organs affected is the kidneys, resulting in sepsis associated acute kidney injury (SA-AKI) that ... contributes to the morbidity and mortality of sepsis. A growing body of knowledge has illuminated the clinical ...

  2. Clinical Review

    Sepsis: pathophysiology and clinical management

    Jeffrey E Gotts, Michael A Matthay
    (Published 23 May 2016)

    Jeffrey E Gotts , assistant professor 1 , Michael A Matthay , professor ... Abstract Sepsis, severe sepsis, and septic shock represent increasingly severe systemic inflammatory ... responses to infection. Sepsis is common in the aging population, and it disproportionately affects patients ...

  3. Clinical Review

    Lesson of the week: Man's best friend: life threatening sepsis after minor dog bite

    D J Mellor, Sunil Bhandari, K Kerr, A R Bodenham
    (Published 11 January 1997)

    may present later due to insidiously developing, local or systemic infection. Catastrophic sepsis ... septicaemia. After a full sepsis screen, including blood cultures, he received 1 g of intravenous cefotaxime. ... – 3 . 7. ↵ Krol-van Straaten MJ, Landheer JE, de Maat CEM. Capnocytophaga canimorsus (formerly ...

  4. Clinical Review

    Management of sepsis

    Iain Mackenzie, Andrew Lever
    (Published 01 November 2007)

    epidemiology, and diagnosis of sepsis, whereas this one focuses on management and outcome. Management of sepsis ... methylene blue, and the phosphodiesterase inhibitors, to support the circulation in sepsis remains to be ... Many patients with severe sepsis, even without pulmonary sepsis, need respiratory support because of ...

  5. Clinical Review

    Secondary peritonitis: principles of diagnosis and intervention

    James T Ross, Michael A Matthay, Hobart W Harris
    (Published 18 June 2018)

    and is the second leading cause of sepsis in patients in intensive care units globally. Overall ... mortality is 6%, but mortality rises to 35% in patients who develop severe sepsis. Despite the dramatic ... sepsis, discuss the utility and limitations of the physical examination and laboratory and radiographic ...

  6. Research

    Impact of sepsis on risk of postoperative arterial and venous thromboses: large prospective cohort study

    Jacques D Donzé, Paul M Ridker, Samuel R G Finlayson, David W Bates
    (Published 08 September 2014)

    preoperative sepsis on risk of postoperative arterial and venous thromboses. Design Prospective ... sepsis had three times the odds of having an arterial or venous postoperative thrombosis (odds ratio 3.1, ... sepsis, and 5.7 (5.4 to 6.1) in patients with severe sepsis, compared with patients without any systemic ...

  7. Research

    Management of severe sepsis in patients admitted to Asian intensive care units: prospective cohort study

    Jason Phua, Younsuck Koh, Bin Du, Yao-Qing Tang, Jigeeshu V Divatia, Cheng Cheng Tan, Charles D Gomersall, Mohammad Omar Faruq, Babu Raja Shrestha, Nguyen Gia Binh, Yaseen M Arabi, Nawal Salahuddin, Bambang Wahyuprajitno, Mei-Lien Tu, Ahmad Yazid Haji Abd Wahab, Akmal A Hameed, Masaji Nishimura, Mark Procyshyn, Yiong Huak Chan
    (Published 13 June 2011)

    hospitals to the Surviving Sepsis Campaign’s resuscitation and management bundles. Secondary objectives were ... intensive care units in 16 Asian countries. Participants 1285 adult patients with severe sepsis admitted ... Sepsis Campaign’s resuscitation (six hours) and management (24 hours) bundles. Results Hospital ...

  8. Research

    Hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis

    Nicolai Haase, Anders Perner, Louise Inkeri Hennings, Martin Siegemund, Bo Lauridsen, Mik Wetterslev, Jørn Wetterslev
    (Published 15 February 2013)

    bleeding, and serious adverse events in patients with sepsis. Design Systematic review with meta-analyses ... albumin in patients with sepsis. Published and unpublished trials were included irrespective of language ... trials that randomised 3456 patients with sepsis were included. Overall, hydroxyethyl starch ...

  9. Clinical Review

    Sepsis in children

    Adrian Plunkett, Jeremy Tong
    (Published 09 June 2015)

    adrian.plunkett{at} The bottom line The initial clinical presentation of sepsis in children may be ... non-specific (especially in younger age groups) Given the time critical nature of severe sepsis and septic ... shock, when sepsis is suspected on clinical grounds it is usually best to start investigations and ...

  10. Clinical Review

    Sepsis: definition, epidemiology, and diagnosis

    Andrew Lever, Iain Mackenzie
    (Published 25 October 2007)

    14 September 2007 On 29 March 2005 a 41 year old journalist died of sepsis six days after a minor ... under the care of any, and every, medical specialty. Summary points Sepsis encompasses a spectrum ... of illness that ranges from minor signs and symptoms through to organ dysfunction and shock Sepsis ...