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  1. News

    Knowledge gaps about Tamiflu and Relenza for pandemic flu are blamed on research failure

    Nigel Hawkes
    (Published 08 October 2015)

    antiviral drugs such as oseltamivir (Tamiflu) and zanamivir (Relenza) work against pandemic strains of flu. ... spent by the UK government on stockpiling Tamiflu in 2009, plus another £136m on Relenza, money wasted? ... Tamiflu. Results will be analysed as they are generated, rather than after the trial is over, so that ...

  2. Research News

    Study claiming Tamiflu saved lives was based on “flawed” analysis

    Zosia Kmietowicz
    (Published 19 March 2014)

    (marketed as Tamiflu). The study was funded by Roche, the manufacturer of oseltamivir, and published this ... on its drug, zanamivir (Relenza). The companies released the complete summary reports of published ... . OpenUrl FREE Full Text ↵ Cohen D. Roche offers researchers access to all Tamiflu trials. ...

  3. Analysis

    Neuraminidase inhibitors—the story behind the Cochrane review

    Peter Doshi
    (Published 08 December 2009)

    (Tamiflu) lowers serious complications of influenza such as pneumonia. We failed, but in failing discovered ... Roche, apparently did not itself make any such claims about complications. A Tamiflu.com webpage reads, ... “Treatment with TAMIFLU has not been proven to have a positive impact on these outcomes,” referring to ...

  4. Analysis

    Rethinking credible evidence synthesis

    Peter Doshi, Mark Jones, Tom Jefferson
    (Published 17 January 2012)

    changed our understanding of oseltamivir (Tamiflu) and our feelings about the viability of reliable ... confirmed, the product information sheet’s statement that “treatment with Tamiflu did not impair normal ... trial programme in perhaps more detail than anyone outside of Roche, states that “Tamiflu has not been ...

  5. Research

    Zanamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments

    Carl J Heneghan, Igho Onakpoya, Matthew Thompson, Elizabeth A Spencer, Mark Jones, Tom Jefferson
    (Published 09 April 2014)

    unpublished. On 14 February 2013, GSK, the manufacturer of zanamivir (Relenza), delivered the first of several ... the BMJ open data campaign at www.bmj.com/open-data/relenza . Selection of studies We included ... Tamiflu, and in a labour case on influenza vaccines in healthcare workers in Canada. In 1997-99, TJ acted ...

  6. Research

    Neuraminidase inhibitors for treatment and prophylaxis of influenza in children: systematic review and meta-analysis of randomised controlled trials

    Matthew Shun-Shin, Matthew Thompson, Carl Heneghan, Rafael Perera, Anthony Harnden, David Mant
    (Published 10 August 2009)

    clinical trials that includes the ISRCTN register). Search terms were “relenza” OR “zanamivir” OR “tamiflu ... inhibitors. 7 Oseltamivir (Tamiflu) is administered orally and in the UK is licensed for the treatment and ... postexposure prophylaxis of influenza in children aged over 1. Zanamivir (Relenza) is inhaled as a dry powder ...

  7. Research

    Neuraminidase inhibitors for preventing and treating influenza in healthy adults: systematic review and meta-analysis

    Tom Jefferson, Mark Jones, Peter Doshi, Chris Del Mar
    (Published 08 December 2009)

    zanamivir (Relenza; Glaxo Wellcome) and oral oseltamivir (Tamiflu; Gilead Sciences and F Hoffmann-La Roche), ... Agency. Tamiflu. Annex 1: summary of product characteristics. p10, 2009. ... www.emea.europa.eu/humandocs/PDFs/EPAR/tamiflu/emea-combined-h402en.pdf . ↵ US Food and Drug Administration (FDA). CFR—Code of Federal Regulations Title 21. ...

  8. News

    Canadian government ordered to release unpublished Tamiflu data in landmark ruling

    Gareth Iacobucci
    (Published 13 July 2018)

    unpublished clinical trial data relating to Tamiflu, Relenza, and three human papillomavirus vaccines ... Canada refused his request to obtain unpublished information relating to Tamiflu, Relenza, Gardasil, ...

  9. News

    Roche offers researchers access to all Tamiflu trials

    Deborah Cohen
    (Published 04 April 2013)

    first asked Roche for the full clinical study reports for its influenza drug oseltamivir (Tamiflu), the ... life cycle leader for Tamiflu at Roche, emailed the Cochrane researchers on 2 April to propose ... GlaxoSmithKline’s decision to release 30 clinical study reports on its influenza drug zanamivir (Relenza) to the ...

  10. News

    Tamiflu purchase worth £49m will go ahead, government says

    Ingrid Torjesen
    (Published 15 April 2014)

    £49m (€60m; $80m) replacing stocks of oseltamivir (Tamiflu) that are due to expire, so as to maintain ... the clinical trials on oseltamivir and zanamivir (Relenza) conducted by their respective ... the stockpiling of Tamiflu, which recommended that once the Cochrane Collaboration review was ...

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