Research Articles

The methodological quality of individual participant data meta-analysis on intervention effects: systematic review

Associations of healthy lifestyle and socioeconomic status with mortality and incident cardiovascular disease: two prospective cohort studies

Continued versus discontinued oxytocin stimulation in the active phase of labour (CONDISOX): double blind randomised controlled trial

Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource

E-health StandingTall balance exercise for fall prevention in older people: results of a two year randomised controlled trial

Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study

Adherence to the test, trace, and isolate system in the UK: results from 37 nationally representative surveys

Update to living systematic review on drug treatments for covid-19

Short term associations of ambient nitrogen dioxide with daily total, cardiovascular, and respiratory mortality: multilocation analysis in 398 cities

Association of spontaneous abortion with all cause and cause specific premature mortality: prospective cohort study

Comparative efficacy of interventions for reducing symptoms of depression in people with dementia: systematic review and network meta-analysis

Age dependent associations of risk factors with heart failure: pooled population based cohort study

Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England

Clustering and longitudinal change in SARS-CoV-2 seroprevalence in school children in the canton of Zurich, Switzerland: prospective cohort study of 55 schools

Trends in obesity and adiposity measures by race or ethnicity among adults in the United States 2011-18: population based study

Changes in soft drinks purchased by British households associated with the UK soft drinks industry levy: controlled interrupted time series analysis

Update to living systematic review on covid-19 in pregnancy

Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study

Early surgical reconstruction versus rehabilitation with elective delayed reconstruction for patients with anterior cruciate ligament rupture: COMPARE randomised controlled trial

Treatment effects in randomised trials using routinely collected data for outcome assessment versus traditional trials: meta-research study

High flow oxygen and risk of mortality in patients with a suspected acute coronary syndrome: pragmatic, cluster randomised, crossover trial

SARS-CoV-2 lateral flow assays for possible use in national covid-19 seroprevalence surveys (React 2): diagnostic accuracy study

Instrumental variable meta-analysis of aggregated randomized drug trial data for evaluating proposed target mechanisms

Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis

Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials

Effect of screening by clinical breast examination on breast cancer incidence and mortality after 20 years: prospective, cluster randomised controlled trial in Mumbai

Excess mortality in Wuhan city and other parts of China during the three months of the covid-19 outbreak: findings from nationwide mortality registries

Covid-19 deaths in Africa: prospective systematic postmortem surveillance study

Food anaphylaxis in the United Kingdom: analysis of national data, 1998-2018

Use of SNP chips to detect rare pathogenic variants: retrospective, population based diagnostic evaluation

Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study

Association of first trimester prescription opioid use with congenital malformations in the offspring: population based cohort study

Association between use of macrolides in pregnancy and risk of major birth defects: nationwide, register based cohort study

Association between antihypertensive treatment and adverse events: systematic review and meta-analysis

Prospective validation of Canadian TIA Score and comparison with ABCD2 and ABCD2i for subsequent stroke risk after transient ischaemic attack: multicentre prospective cohort study

Use of high dose cyproterone acetate and risk of intracranial meningioma in women: cohort study

Associations of cereal grains intake with cardiovascular disease and mortality across 21 countries in Prospective Urban and Rural Epidemiology study: prospective cohort study

Update to living systematic review on prediction models for diagnosis and prognosis of covid-19

Effect of redundant clinical trials from mainland China evaluating statins in patients with coronary artery disease: cross sectional study

Association between human papillomavirus vaccination and serious adverse events in South Korean adolescent girls: nationwide cohort study

Association between county level cannabis dispensary counts and opioid related mortality rates in the United States: panel data study

Efficacy and safety of antidepressants for the treatment of back pain and osteoarthritis: systematic review and meta-analysis

Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial

Home and Online Management and Evaluation of Blood Pressure (HOME BP) using a digital intervention in poorly controlled hypertension: randomised controlled trial

Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial

Efficacy and safety of low and very low carbohydrate diets for type 2 diabetes remission: systematic review and meta-analysis of published and unpublished randomized trial data

Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials

Use of proton pump inhibitors to treat persistent throat symptoms: multicentre, double blind, randomised, placebo controlled trial

Association between home insulation and hospital admission rates: retrospective cohort study using linked data from a national intervention programme

Update to living systematic review on drug treatments for covid-19

Does medicine run in the family—evidence from three generations of physicians in Sweden: retrospective observational study

Association of high profile football matches in Europe with traffic accidents in Asia: archival study

Effectiveness of hospital clowns for symptom management in paediatrics: systematic review of randomised and non-randomised controlled trials

Estimating my equilibrium energy intake during lockdown: very introspective study

Comparative evaluation of clinical manifestations and risk of death in patients admitted to hospital with covid-19 and seasonal influenza: cohort study

Global, regional, and national estimates of target population sizes for covid-19 vaccination: descriptive study

Reserving coronavirus disease 2019 vaccines for global access: cross sectional analysis

Nonsensus in the treatment of proximal humerus fractures: uncontrolled, blinded, comparative behavioural analysis between Homo chirurgicus accidentus and Macaca sylvanus

Effect of therapeutic suggestions during general anaesthesia on postoperative pain and opioid use: multicentre randomised controlled trial

The shared risk of diabetes between dog and cat owners and their pets: register based cohort study

Toxicological analysis of George’s marvellous medicine: literature review

Patient mortality after surgery on the surgeon’s birthday: observational study

The Babinski sign in Renaissance paintings—a reappraisal of the toe phenomenon in representations of the Christ Child: observational analysis

The time to act is now: pseudo-systematic review

Association between conflicts of interest and favourable recommendations in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews: systematic review

Association between low density lipoprotein and all cause and cause specific mortality in Denmark: prospective cohort study

Red meat intake and risk of coronary heart disease among US men: prospective cohort study

Cancer risk in individuals with major birth defects: large Nordic population based case-control study among children, adolescents, and adults

Clinical spectrum of coronavirus disease 2019 in Iceland: population based cohort study

Active conventional treatment and three different biological treatments in early rheumatoid arthritis: phase IV investigator initiated, randomised, observer blinded clinical trial

Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain: nationwide seroepidemiological study

Gestational age and hospital admissions during childhood: population based, record linkage study in England (TIGAR study)

Association between neuraxial anaesthesia or general anaesthesia for lower limb revascularisation surgery in adults and clinical outcomes: population based comparative effectiveness study

Treatment interventions to maintain abstinence from alcohol in primary care: systematic review and network meta-analysis

First line drug treatment for hypertension and reductions in blood pressure according to age and ethnicity: cohort study in UK primary care

Pregravid contraceptive use and fecundability: prospective cohort study

Accuracy of UK Rapid Test Consortium (UK-RTC) “AbC-19 Rapid Test” for detection of previous SARS-CoV-2 infection in key workers: test accuracy study

Accuracy of the Edinburgh Postnatal Depression Scale (EPDS) for screening to detect major depression among pregnant and postpartum women: systematic review and meta-analysis of individual participant data

Consistency of variety of machine learning and statistical models in predicting clinical risks of individual patients: longitudinal cohort study using cardiovascular disease as exemplar

Mortality due to cancer treatment delay: systematic review and meta-analysis

Associations between high temperatures in pregnancy and risk of preterm birth, low birth weight, and stillbirths: systematic review and meta-analysis

Effect of monitoring surgical outcomes using control charts to reduce major adverse events in patients: cluster randomised trial

Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases

Risk of hospital admission with coronavirus disease 2019 in healthcare workers and their households: nationwide linkage cohort study

Influence and management of conflicts of interest in randomised clinical trials: qualitative interview study

Autocratisation and universal health coverage: synthetic control study

Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial)

Regulatory T cells for minimising immune suppression in kidney transplantation: phase I/IIa clinical trial

Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from coronavirus 19 in adults: national derivation and validation cohort study