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Identifying women with suspected ovarian cancer in primary care: derivation and validation of algorithm

BMJ 2012; 344 doi: https://doi.org/10.1136/bmj.d8009 (Published 04 January 2012) Cite this as: BMJ 2012;344:d8009

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Re: Identifying women with suspected ovarian cancer in primary care: derivation and validation of algorithm

Authors have used red flag symptoms e.g. abdominal distension, weight loss, post-menopausal bleeding etc for exclusion criteria at the time of recruitment. Development of these symptoms in follow-up were taken as outcome variable as well. Author should also have done a bi-manual examination, an ultrasound and estimation of CA-125 for exclusion of ovarian cancer at recruitment and its development in the follow-up for estimating the validity and measurement of risk factors (along with red flag symptoms). Very surprisingly authors have not used ultrasound and bi-manual examination in the study, which would have been handy and valid.

Competing interests: No competing interests

09 February 2012
Neeru Gupta
Scientist E
Indian Council of Medical Research
V.Ramalingaswamy Bhawan, Ansari Nagar, Delhi-110029