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Research

Risk of non-fatal venous thromboembolism in women using oral contraceptives containing drospirenone compared with women using oral contraceptives containing levonorgestrel: case-control study using United States claims data

BMJ 2011; 342 doi: https://doi.org/10.1136/bmj.d2151 (Published 21 April 2011) Cite this as: BMJ 2011;342:d2151

Rapid Response:

All risk factors of thromboembolism should have been excluded

Dear Editor,

All risk factors predisposing to thromboembolism such as Obesity,
smoking, prolonged immobilization and previous history of thromboembolism
should have been excluded or matched before interpreting the data on
thromboembolism in women taking oral contraceptives. Or the confounding
should have been adjusted while interpreting the data.The article(1) does
exclude other risk factors, such as any history of cancer (other than non
-melanoma skin cancer), renal failure, chronic cardiovascular disease, or
inflammatory or autoimmune conditions, severe lower limb injury, major
surgery, severe trauma, or pregnancy. The above stated risk factors are
relative or absolute contradictions for administering oral contraceptive.

Reference:

1. Jick SS and Hernandez RK. Risk of non-fatal venous thromboembolism
in women using oral contraceptives containing drospirenone compared with
women using oral contraceptives containing levonorgestrel: case-control
study using United States claims data BMJ 2011 342:d2151;
doi:10.1136/bmj.d2151

Competing interests: No competing interests

23 April 2011
Neeru Gupta
Scientist E
Indian Council of Medical Research