What about Pseudodementias and Mood disorders?
Prof Julia Hippisley-Cox's paper on unintended effects of statins is
timely in confirming knowledge that is the province of excellent Clinical
Pharmacologists. The latter warn us that all drugs have potential side-
effects.Placebos cause nocebo responses. Pharmacovigilance ultimately
confirms numerous adverse drug events. I note, however, that Hippisley-
Cox's paper has no serious comment about mood disorders which do occur at
least in the elderly (1). Quantifying this side effect of statins is
difficult hence remains easily dismissed. A London coroner linked
simvastatin to a death in a patient who had mood changes following
inception of the statin treatment (2). Exact mechanism causing these
affective disorders is unclear.
1. Knashawn et al Simvastatin Causes Changes in Affective Processes
in Elderly Volunteers J Am Geriatr Soc. 2006;54(1):70-76.
2. Sunday Times January 13th 2008. Cholesterol drug linked to teacher's
Competing interests: No competing interests