Once again the legend of metformin induced Lactic Acidosis is
resurrected.I refer all readers to the most recent Cochrane Database Syst
Rev 2010 Jan 20;(1) : CD002967 (Review) by SR Salpeter,et.al.
The authors conclusions after reviewing 347 comparative trials and
cohort studies including 70,490 patient years of metformin use and 55,451
patient years in the non-metformin group were:"There is no evidence from
prospective comparative trials or from observational cohort studies that
metformin is associated with an increased risk of lactic acidosis,or
withincreased levels of lactate, compared to other anti-hyperglycemic
It is time for this piece of medical mythology to RIP.
Competing interests: No competing interests