Antibiotic induced psychosis or Hoigné’s syndrome
Bell et al. report on a 55 year old woman who suffered an acute onset
of agitation and psychosis in the context of exposure to a combination of
amoxicillin and clavulanate. It is worth noting that reactions of this
type have been previously labelled as Hoigné’s syndrome following numerous
similar descriptions associated with penicillin use in the 1950’s (1).
Whether or not Bell’s case is best described as Hoigné’s or antibiomania -
another term found in the literature, or simply, and possibly preferably,
antibiotic-induced psychosis, those interested in the phenomena will
benefit from using these terms when searching the literature (2).
1. Hoigné R, Schock K. Anaphylactic shock and acute nonallergic
reactions following procaine-penicillin. Schweiz Med Wochenschr 1959; 89:
2. Abouesh A, Stone C, Hobbs WR. Antimicrobial-induced mania
(antibiomania): a review of spontaneous reports. J Clin Psychopharmacol
2002; 22: 71–81.
Competing interests: No competing interests