Advances in glucocorticoid induced osteoporosis ( GIOP)
The association of glucosorticoid induced osteoporosis (GIOP) is well
known since 1932 .This is the most common cause of secondary oetoporosis
.There is a bone loss of more than 30 percent in the first few months of
starting steroids. Antiresorptive agents like bisphosphonate have a clear
prognostic role. Health provider should recognise the recommendation for
treatment with bone risk estimation scale – FRAX. There is no doubt that
this reduces the incidence of fracture .However there still remains a
considerable variation in individual practises and an underutilisation of
DEXA scanning .The other novel treatment are –
pamidronate,treiparatide.There is a proven role of receptor activated
nuclear factor kappa B ligand osteoprotogenin system (1) which will lead
to better therapies .
1.Reid LR et al .Prevention of glucocorticoid-induced oetoporosis .Journal
of bone and mineral research.June 1990 vol./is.5/6 (619-23).
Competing interests: No competing interests