Intended for healthcare professionals


Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort study

BMJ 2007; 335 doi: (Published 19 July 2007) Cite this as: BMJ 2007;335:136

Doubts about QRISK score: total / HDL cholesterol should be important.

In the report of the QRISK cardiovascular disease risk score the
ratio of total to HDL cholesterol appears to be of no relevance to the
incidence of disease, despite the large size of the study population. This
is very different from what has been reliably found in other studies. The
contrast is so sharp that it suggests some serious error in the
collection, processing or analysis of the QRISK data.

Until more details of the materials and methods of this new QRISK
study are made available, the reliable conclusion should be retained from
previous studies that the ratio of total to HDL cholesterol (undistorted
by lipid-lowering drugs) is strongly predictive of the primary incidence
of coronary disease.

Competing interests:
None declared

Competing interests: No competing interests

13 July 2007
Richard Peto
Professor of Medical Statistics and Epidemiology
CTSU, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF