Intended for healthcare professionals

Rapid response to:


Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis

BMJ 2003; 326 doi: (Published 26 June 2003) Cite this as: BMJ 2003;326:1423

Rapid Response:

Cholesterol and Ischemic heart disease

A recent study by Ward et al published in the BMJ about the variation
in how the variation in Cholesterol levels overtime decreases the
estimation of the link between ischemic heart disease and Cholesterol. On
correcting for both the variation in Cholesterol and the variation in LDL
(which has a stronger link to heart disease) in a cohort of more than 5000
patients they established that the link to IHD is underestimated. They
also found that interventions to reduce LDL may be more useful in reducing
Cholesterol than previously thought. According to their data in middle
aged men lowering LDL by 0.6 mmol/l may reduce IHD risk by 25-30%.[1]

[1]BMJ 1994;308:363-366 Systematic underestimation of association
between serum cholesterol concentration and ischemic heart disease in
observational studies: data from the BUPA study
M R Law, N J Wald, T Wu, A Hackshaw, A Bailey

Competing interests:
None declared

Competing interests: No competing interests

27 February 2008
Ravi Ponnada
Research Fellow
Mahmood Ahmad
Epsom General Hospital, Dorking Road, KT18 7EG