Surely some mistake?
Ravnskov et al., state that 'all statins inhibit the synthesis of
hydroxymethylglutaryl coenzyme A (HMG CoA) reductase, an enzyme involved
in synthesis of the precursor of cholesterol'. This is incorrect. Statins
act as inhibitors of hydroxymethylglutaryl coenzyme A reductase and reduce
synthesis of mevalonate from HMG CoA. The consequent reduction in
cholesterol synthesis leads to upregulation of receptors for low density
lipoprotein (LDL) and a resultant increase in uptake of this lipoprotein
(largely by the liver) and reduced circulating LDL. In fact use of statins
is associated with increased amounts of HMG CoA reductase as a result of
reduced negative feedback on synthesis (1).
1. Brown MS, Goldstein JL. Multivalent feedback regulation of HMG CoA
reductase, a control mechanism coordinating isoprenoid synthesis and cell
growth. J Lipid Res. 1980;21:505-17.
Competing interests: No competing interests