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Impact of Helicobacter pylori eradication on dyspepsia, health resource use, and quality of life in the Bristol helicobacter project: randomised controlled trial

BMJ 2006; 332 doi: https://doi.org/10.1136/bmj.38702.662546.55 (Published 26 January 2006) Cite this as: BMJ 2006;332:199

Rapid Response:

Screening vs. testing symptomatic patients

This trial found a 3.3% absolute difference in the proportion of
patients consulting primary care physicians for dyspepsia over 2 years
following H. pylori eradication.

There was a 2.3% absolute difference in the baseline rates of
dyspepsia symptoms -- 24.3% of intervention patients and 26.6% fo placebo
patients. This could account for much of the difference in the primary
outcome.

Could the authors provide subgroup analyses of results in patients
with dyspepsia symptoms at baseline and for patients without dyspepsia
symptoms at baseline? This might suggest whether the screening could be
limited to symptomatic patients without reducing efficacy.

Competing interests:
None declared

Competing interests: No competing interests

05 February 2006
Brian S. Alper
Editor-in-Chief
www.DynamicMedical.com