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Chronic stress at work and the metabolic syndrome: prospective study

BMJ 2006; 332 doi: (Published 02 March 2006) Cite this as: BMJ 2006;332:521

Retinoid X Receptor Heterodimers and Metabolic Syndrome

Dear Editor,

The major sequelae of metabolic syndrome, also known as syndrome X
are cardiovascular disease and type 2 diabetes mellitus, but the syndrome
also increases the risk of polycystic ovary syndrome, fatty liver,
cholesterol gallstones, asthma, sleep disturbances, and some forms of
cancer.Nuclear receptors are transcription factors that serve as
intracellular receptors for endocrine hormones and dietary lipids.The
retinoid X receptor (RXR), a member of the nuclear-receptor superfamily,
is a common binding partner for a subgroup of other nuclear receptors. The
resulting functional complex of one RXR molecule with one distinct nuclear
-receptor molecule is known as a heterodimer. Drugs that target RXR and
its heterodimerization partners are are important in clinical use for the
treatment of cancer, dermatologic diseases, endocrine disorders, and the
metabolic syndrome.
Shulman AI, Mangelsdorf DJ. Retinoid X receptor heterodimers in the
metabolic syndrome. N Engl J Med 2005;353:604-615.

Competing interests:
None declared

Competing interests: No competing interests

05 March 2006
Prasanta Padhan
MD,Senior Resident.
Dept. Of Internal Medicine,JIPMER,Pondicherry,India.605006