Intended for healthcare professionals

Rapid response to:

Papers

Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study

BMJ 2005; 331 doi: https://doi.org/10.1136/bmj.38551.446470.06 (Published 06 October 2005) Cite this as: BMJ 2005;331:807

Rapid Response:

Re folate intake, alcohol and breast cancer risk

Dear Editor,

1) When the exposure of alcohol and folate were measured,[1] the
exposure periods of the two substances would be needed to evaluate the
total doses of exposure.

2) People who have a high folate intake (>400 micrograms/ per day)
are more likely to take care of their health: they are likely to have
higher physical activity level, consume a balance diet, consume “better”
alcohol, pay more attention to or even overestimate their risk
factors—they may overestimate the amount of alcohol that they have drunk.

People who have high alcohol consumption (>40g/day) and low folate
consumption may have more problems with their health, therefore they may
visit their GPs more frequently, and high alcohol intake may draw the GPs’
attention to their potential breast cancer risk. This might increase the
“risk” of these people to be early diagnosed.

A further comparison of baseline characters between these two small
groups (people who consume >40g alcoholic drinks, and consume either
less than 200micrograms or more than 400 micrograms) may be appropriate.

Reference:

1. Baglietto, L., et al., Does dietary folate intake modify effect of
alcohol consumption on breast cancer risk? Prospective cohort study. Bmj,
2005.

Competing interests:
None declared

Competing interests: No competing interests

07 October 2005
Wenbin Liang
taking master of public health
Curtin University of Technology