The article by Laumon et al. (2005) supports the assumption of a low
risk of cannabis use to cause accidents and a dose-effect relationship
observed in previous studies (Drummer et al. 2004, Longo et al. 2001). The
results have been cited in the popular media stating that cannabis users
face a three times greater risk of being responsible for a fatal road
crash. But the results do not support this conclusion. The presentation of
the results in the abstract is somewhat misleading, which may have caused
this misinterpretation. The figures for the unadjusted odds ratios suggest
a more than threefold risk increase for all THC positive drivers and a
more than twofold increase even for drivers with a THC blood concentration
of less than 1 ng/ml. However, closer review of the results shows that two
other factors contributed to the higher accident risk, i.e., alcohol
consumption and the younger age of the THC positive drivers, compared to
the whole cohort.
About 42% (285/681) of THC positive drivers also tested positive for
alcohol, with a blood alcohol concentration (BAC) of 0.05%, which was
associated with an increased risk of 8.5. Even a BAC below 0.05% was
reported to be associated with an odds ratio of 2.7 in the study, but no
data were given on the percentage of THC positive drivers with an
additional BAC <0.05%. Thus, no information is available on drivers
who had only THC in their blood and on their risk of causing an accident,
which has been used as a standard way of reporting in previous studies
(e.g. Drummer et al. 2004, Longo et al. 2001). Laumon et al. (2005) were
careful not to over-adjust the risk for cannabis use, but they may have
under-adjusted it and it remains unclear if there is indeed an increased
risk for THC blood concentrations below 3 ng/ml in their cohort.
Previous epidemiological data and results from experimental studies
prompted an international working group to make a suggestion for legal THC
limits in blood comparable to BAC limits for alcohol to separate impaired
from non-impaired drivers (Grotenhermen et al. 2004). The study by Laumon
et al. (2005) is well in agreement with the proposal of a legal limit of a
THC blood concentration in the range of 3-5 ng/ml (corresponding to about
6-10 ng/ml in blood serum) made by this group.
1. Drummer OH, Gerostamoulos J, Batziris H, Chu M, Caplehorn J,
Robertson MD, Swann P. The involvement of drugs in drivers of motor
vehicles killed in Australian road traffic crashes. Accid Anal Prev
2004;36(2):239-48.
2. Grotenhermen F, Leson G, Berghaus G, Drummer O, Krüger HP, Longo M,
Moskowitz H, Perrine B, Ramaekers J, Smiley A, Tunbridge R. Developing
Per Se Laws for Driving Under the Influence of Cannabis (DUIC). Abstract
presented at the 17th International Conference on Alcohol, Drugs and
Traffic Safety (ICADTS), 8-13 August 2004, Glasgow, UK.
3. Laumon B, Gadegbeku B, Martin JL, Biecheler MB. Cannabis intoxication
and fatal road crashes in France: population based case-control study. BMJ
2005 Dec 2 [electronic publication ahead of print]
4. Longo MC, Hunter CE, Lokan RJ, White JM, White MA. The prevalence of
alcohol, cannabinoids, benzodiazepines and stimulants amongst injured
drivers and their role in driver culpability: part ii: the relationship
between drug prevalence and drug concentration, and driver culpability.
Accid Anal Prev 2000;32(5):623-32.
Rapid Response:
Presentation of the results is misleading
Dear Sirs:
The article by Laumon et al. (2005) supports the assumption of a low
risk of cannabis use to cause accidents and a dose-effect relationship
observed in previous studies (Drummer et al. 2004, Longo et al. 2001). The
results have been cited in the popular media stating that cannabis users
face a three times greater risk of being responsible for a fatal road
crash. But the results do not support this conclusion. The presentation of
the results in the abstract is somewhat misleading, which may have caused
this misinterpretation. The figures for the unadjusted odds ratios suggest
a more than threefold risk increase for all THC positive drivers and a
more than twofold increase even for drivers with a THC blood concentration
of less than 1 ng/ml. However, closer review of the results shows that two
other factors contributed to the higher accident risk, i.e., alcohol
consumption and the younger age of the THC positive drivers, compared to
the whole cohort.
About 42% (285/681) of THC positive drivers also tested positive for
alcohol, with a blood alcohol concentration (BAC) of 0.05%, which was
associated with an increased risk of 8.5. Even a BAC below 0.05% was
reported to be associated with an odds ratio of 2.7 in the study, but no
data were given on the percentage of THC positive drivers with an
additional BAC <0.05%. Thus, no information is available on drivers
who had only THC in their blood and on their risk of causing an accident,
which has been used as a standard way of reporting in previous studies
(e.g. Drummer et al. 2004, Longo et al. 2001). Laumon et al. (2005) were
careful not to over-adjust the risk for cannabis use, but they may have
under-adjusted it and it remains unclear if there is indeed an increased
risk for THC blood concentrations below 3 ng/ml in their cohort.
Previous epidemiological data and results from experimental studies
prompted an international working group to make a suggestion for legal THC
limits in blood comparable to BAC limits for alcohol to separate impaired
from non-impaired drivers (Grotenhermen et al. 2004). The study by Laumon
et al. (2005) is well in agreement with the proposal of a legal limit of a
THC blood concentration in the range of 3-5 ng/ml (corresponding to about
6-10 ng/ml in blood serum) made by this group.
Sincerely,
Franjo Grotenhermen, M.D.
nova-Institut,
Goldenbergstrasse 2,
50354 Huerth,
Germany
References
1. Drummer OH, Gerostamoulos J, Batziris H, Chu M, Caplehorn J,
Robertson MD, Swann P. The involvement of drugs in drivers of motor
vehicles killed in Australian road traffic crashes. Accid Anal Prev
2004;36(2):239-48.
2. Grotenhermen F, Leson G, Berghaus G, Drummer O, Krüger HP, Longo M,
Moskowitz H, Perrine B, Ramaekers J, Smiley A, Tunbridge R. Developing
Per Se Laws for Driving Under the Influence of Cannabis (DUIC). Abstract
presented at the 17th International Conference on Alcohol, Drugs and
Traffic Safety (ICADTS), 8-13 August 2004, Glasgow, UK.
3. Laumon B, Gadegbeku B, Martin JL, Biecheler MB. Cannabis intoxication
and fatal road crashes in France: population based case-control study. BMJ
2005 Dec 2 [electronic publication ahead of print]
4. Longo MC, Hunter CE, Lokan RJ, White JM, White MA. The prevalence of
alcohol, cannabinoids, benzodiazepines and stimulants amongst injured
drivers and their role in driver culpability: part ii: the relationship
between drug prevalence and drug concentration, and driver culpability.
Accid Anal Prev 2000;32(5):623-32.
Competing interests:
None declared
Competing interests: No competing interests