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Clinical Review

Obsessive-compulsive disorder

BMJ 2006; 333 doi: (Published 24 August 2006) Cite this as: BMJ 2006;333:424

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Obsessive-compulsive disorder: a review

Obsessive-compulsive disorder: a review

EDITOR - We will discuss the article by Heyman et al1 with related reports
published recently on obsessive compulsive disorder (OCD).

The results of genetic studies in family have demonstrated
significantly higher rates of OCD in parents and siblings of OCD probands
with an age-corrected morbid risk ranging from approximately 10% to 35% in
first-degree relatives2. In a case series, Sutor et al3 reported four
cases of patients with Down syndrome with symptoms consistent with OCD.
Grant et al4 examined sexual obsessions and clinical correlates in adults
with OCD and reported that subjects with sexual obsessions had an earlier
age of onset of OCD than subjects without these symptoms, and subjects
with current sexual obsessions were significantly more likely to report
current aggressive (P <.001) and religious (P = .001) obsessions, as
compared to those without these symptoms.

The long-term efficacy and adverse cognitive effects of stereotactic
bilateral anterior cingulotomy was investigated as a treatment option for
refractory OCD patients, and was found effective, and no significant
adverse cognitive effects on long-term follow-up were found5.


1.Heyman I, Mataix-Cols D, Fineberg NA. Obsessive-compulsive
disorder. BMJ 2006; 333:424-429. (26 August.)

2.Eapen V, Pauls DL, Robertson MM. The role of clinical phenotypes in
understanding the genetics of obsessive- compulsive disorder. J Psychosom
Res 2006; 61:359-64.

3.Sutor B, Hansen MR, Black JL. Obsessive compulsive disorder
treatment in patients with Down syndrome: a case series. Downs Syndr Res
Pract 2006; 10:1-3.

4.Grant JE, Pinto A, Gunnip M, Mancebo MC, Eisen JL, Rasmussen SA.
Sexual obsessions and clinical correlates in adults with obsessive-
compulsive disorder. Compr Psychiatry 2006; 47:325-9.

5.Jung HH, Kim CH, Chang JH, Park YG, Chung SS, Chang JW. Bilateral
Anterior Cingulotomy for Refractory Obsessive-Compulsive Disorder: Long-
Term Follow-Up Results. Stereotact Funct Neurosurg 2006; 84:184-189.

Competing interests:
None declared

Competing interests: No competing interests

06 September 2006
Dr. Prakash
Assistant Professor, Dept. of Anatomy, Kasturba Medical College, Mangalore, India
Latha V. Prabhu*, Sampath Madhyastha*, Gajendra Singh**.
Kasturba Medical College, Mangalore,India, 575004* & I.M.S., B.H.U., Varanasi, U.P., India, 221005**