Intended for healthcare professionals

Rapid response to:


Emergency naloxone for heroin overdose

BMJ 2006; 333 doi: (Published 21 September 2006) Cite this as: BMJ 2006;333:614

Rapid Response:

Naloxone as a reagent

Naloxone and/or nalorphine are in common use in toxicology
laboratlories as internal standards for chromatographic identification and
quantitation of opiates and other basic drugs. Therapeutic (whether
administered by professional or lay persons) use of naloxone (if known)
should be notified to an investigating laboratory to allow approporiate
changes to be made to analytical methods. Such notification is
particularly important when a rapid analytical response is required (e.g.
in the identification of substances that may obfuscate clinical
examination to determine brain death). Failure to notify will lead to
failure of the analysis through failure of quality assurance checking
procedures thus delaying analysis for entirely avoidable reasons.

Competing interests:
None declared

Competing interests: No competing interests

06 October 2006
Janusz Knepil
Principal Biochemist (Toxicology)
Biochemistry Deoartment, Gartnavel General Hospital, Glasgow. G12 0YN