Intended for healthcare professionals


Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review

BMJ 2006; 332 doi: (Published 30 March 2006) Cite this as: BMJ 2006;332:752

High Quality Randomised Controlled Studies needed to determine risks and benefits of omega 3 fats

On the recommendations for high quality RTCs, long duration with
allocation concealment and masking to study the effects of omega 3 fats by
Lee Hooper et al should be added:

Determine the time it takes for the effects to be detected. The
(induction) time for such effects on mortality, cardiovascular events and
cancer would theoretically be longer than present studies indicate. Even
though measurements in the control group would ensure detection of
difference, knowing the induction period for omega 3 fats related effects
would refine what studies to include in systematic reviews.

Bearing in mind the complexity of the metabolism of food nutrients,
include arms of participants exposed to potently enhancing factors as
probably occurs in nature when people eat fish; because our chief interest
is to find an intervention that helps people whether omega 3 alone or in

Competing interests:
None declared

Competing interests: No competing interests

03 April 2006
Anthony Lwegaba
Lecturer, Public Health
School of Clinical Medicine and Research, UWI, Barbados, WI