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Selective serotonin reuptake inhibitors

BMJ 2005; 330 doi: https://doi.org/10.1136/bmj.330.7488.420-b (Published 17 February 2005) Cite this as: BMJ 2005;330:420

Rapid Response:

THREAD study disappointing

I was delighted when I first read this. At last, a sensible trial not
sponsored by the pharmaceutical industry. Unfortunately when I looked up
the details of this study I discovered it will not be placebo controlled,
some people will have counselling, some CBT or any therapy at the whim of
their GP and what is said to the patients aboout their illness is not
standardised. I suppose if it fails to show a difference between drugs and
"supportive treatment" alone (whatever that means) it could be seen as
evidence that NICE is right. On the other hand, better outcomes for the
fluoxetine treated group could be nothing more than the well known, good
old placebo effect.
Perhaps the authors can explain this deficiency?

Competing interests:
None declared

Competing interests: No competing interests

11 March 2005
Giselle Martinez
consultant psychiatrist
cardiff