Intended for healthcare professionals

Rapid response to:

News Roundup [abridged Versions Appear In The Paper Journal]

Exercise can cut risk of breast cancer

BMJ 2003; 327 doi: (Published 18 September 2003) Cite this as: BMJ 2003;327:640

Rapid Response:

Oncological Terrain, Functional Mitochondrial Cytopathology, and Breast Cancer.

as I recently wrote to JAMA, regarding McTiernanA., et al.’s paper (1),
wherein are referred data from more than 74 000 women between the ages of
50 and 79 years, who participated in the women's health initiative study
from 1993 to 1998, there is once again a fundamental bias in such as
study. In fact, malignancy, like breast cancer, can occur “exclusively” in
individuals involved by a well-defined predisposition, I termed as
“Oncological Terrain”, we can evaluate at the bed-side in a
“quantitative” way (See: web-site HONCode 233736, URL and The
authors clearly overlooke, or better said ignore, the oncological terrain,
and, then, it ‘s impossible for us to know the percentage of women of the
research, with this oncological constitution, who have benefited from
physical exercise, even moderate, if combined with dieting, of course. In
addition, even involved by oncological terrain, a woman may be totally
free of “real risk” of breast cancer (2, 3). As a matter of fact, a woman,
although involved by Oncological Terrain, may present with or without
precise location in a well-defined breast quadrant (“ab posse ad esse non
licet illatio”, Kant, Kritik der reinigen Vernunft). In my opinion, since
a congenital functional mitochondrial cytopathology is overlooked --
"conditio sine qua non" of the most frequent and dangerous human
disorders, including malignancies--all current clinical researches are
fundamentally biased (4). In other words, authors do not consider the
existence or assess the seriousness as well as the location of Congenital
Acidosic Enzyme-Metabolic Histangiopathy (4) (See in above-cited web-
site), conditio sine qua non also of “Oncological Terrain”. In fact, both
environmental risk factors and every drug, including oestrogens, suggested
as a risk factor for breast cancer, "could" influence some human
biological functions and/or bring about different disorders, such as
cancers, exclusively in relation to both the presence, intensity, and
precise location of CAEMH (4), in a well-defined biological system.
Without “Oncological Terrain” there is not oncogenesis.

1) McTiernan A., et al. JAMA 2003;290: 1331-6[Abstract/Free Full

2) Stagnaro S. Paramount bias in “all” cancer screening. (11 July
3) Stagnaro-Neri M., Stagnaro S., Cancro della mammella: prevenzione
primaria e diagnosi precoce con la percussione ascoltata. Gazz. Med. It. –
Arch. Sc. Med. 152, 447, 1993
4) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica. Una
Patologia Mitocondriale Ignorata. Gazz Med. It. – Arch. Sci. Med. 144,
423, 1985 (Infotrieve)

Competing interests:  
None declared

Competing interests: No competing interests

19 September 2003
Sergio Stagnaro
Specialist in Blood, Gastrointestinal, and Metabolic Diseases. Researcher in Biophysical Semeiotics.
Via Erasmo Piaggio 23/8. 16037 Riva Trigoso (Genoa) Italy.