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Primary Care

Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials

BMJ 2005; 330 doi: (Published 17 February 2005) Cite this as: BMJ 2005;330:396

High risk fatal suicide attempts with SSRIs as compared wtih TCAs

Dear authors,
I am a psychiatrist practising in University of Malaya, Malaysia. I read
your systematic review entitles association between suicide attempts and
SSRIs. It is a very interesting review for psychiatrist to read and
I am very greatful if you could clarify to me how could you reach the
conclusion of "the odd ratio of non-fatal suicide attempts was 0.85 and
the odd ratio of fatal suicide attempts for SSRIs compared with tricyclic
antidepressants(TCAs) was 7.27". This indeed a very high value and
interprets a very high risk of fatal suicide attempts in patients treating
with SSRIs as compared to TCAs. It means significant finding in term of my
practice. Therefore, your explanation is very much helpful. Thank you.

Competing interests:
None declared

Competing interests: No competing interests

19 March 2005
Muhammad Muhsin Ahmad Zahari
University of Malaya, Malaya