Intended for healthcare professionals

Rapid response to:

Clinical Review ABC of adolescence

Fatigue and somatic symptoms

BMJ 2005; 330 doi: (Published 28 April 2005) Cite this as: BMJ 2005;330:1012

Rapid Response:

Failure to consider the issue of differential diagnosis now inexcusable.

As a sadly frequent occurrence, we are faced here with yet another
article where the neurological nature of Myalgic Encephalomyelitis/ICD-10
Chronic Fatigue Syndrome (WHO ICD-10) is ignored, in favour of a vaguely
written psychiatric paradigm (Kennedy, 2005) in which a serious, sometimes
severely disabling disease with specific signs and symptoms of Central
Nervous System Dysfunction (Hyde, 1992, 2003) is subsumed under
generalisations of “fatigue and other somatic symptoms“, in which
(according to the author‘s beliefs but not supported by evidence) ‘de-
conditioning’ and ’psycho-social factors’ are claimed as causes.

Simon Wessely may claim (according to Duprey, another RR contributor)
that “it is simplistic to cast the medical care of humanity solely in
psychosocial or biological paradigms“. But, as he has stated there is no
such thing as ME, and has been critiqued for his own and colleague’s
overemphasis on the psycho-social, at the expense of the biological, and
for his prejudicial descriptions of ME/CFS sufferers (Hooper et al, 2004,
Marshall and Williams, 1999, Kennedy, 2005), it would appear to be a case
of ’practice what you preach’.

Proponents of the psychiatric paradigm- which, with the greatest of
respect, Viner and Christie appear to be (unfortunately there is little
evidence to suggest otherwise, and here their ‘bio-psychosocial approach’
lays far too much emphasis on the ‘psychosocial’, to the detriment of the
biological, a frequent occurrence)- consistently fail to discuss the
problem of the issue of ‘fatigue’ as applies to ME/CFS sufferers, thereby
incorrectly presenting ‘fatigue’ as merely ‘tiredness’, despite the
evidence that the word ‘fatigue’ is inadequate to describe the physical
abnormalities (both signs and symptoms) that occur in ME/CFS. In the same
context, they fail to acknowledge that ‘fatigue’ (which might mean
tiredness, drowsiness, exhaustion, disturbed level of consciousness,
weakness, paralysis, or feelings of malaise, depending on how certain
illnesses are experienced or linguistically constructed by individuals) is
present in MOST organic illnesses, acute and chronic. Indeed: “Fatigue is
both a normal and a pathological feature of everyday life’ (Hyde 1992:

Proponents of the psychiatric paradigm, in their literature, tend to
associate ‘fatigue’ with a psychological state, ignoring the physiological
reasons that may contribute to the bodily symptoms in ME/CFS, with the
effect that these become generalised, and often trivialised, as ‘fatigue’.
As Hyde also points out, to place such an emphasis on such a generalised,
unspecific, indefinable and immeasurable term as ‘fatigue’, present in
both healthy patients and those with both organic and psychological
illness, the elimination of hundreds of other diseases are necessitated.
This logistical flaw results in only the most limited investigation being
encouraged for ME/CFS patients, and NOT in areas that might yield
definitive results, such as certain brain scans (as discussed and
referenced in Hyde et al, 1992, Marshall et al, 2001, Carruthers et al,

Particularly relevant to ME/CFS sufferers also is the problem also
identified by Hyde (1992: 11-12):

‘…taking the fatigue as the flagship symptoms of a disease not only
bestows the disease with a certain Rip Van Winkle humour, but removes the
urgency of the fact that most ME/CFS symptoms are in effect CNS symptoms.’

In this context the ramifications of such serious, disabling symptoms
as found in ME/CFS are both trivialised and ignored. The problem is
compounded by the frequent tendency, by proponents of the psychiatric
paradigm themselves and taken up uncritically by others, to use,
incorrectly, the term ‘chronic fatigue’ instead of and interchangeably
with ‘chronic fatigue syndrome’, even though both terms denote completely
different diseases. Chronic Fatigue Syndrome is described in the WHO ICD-
10 as synonymous with (therefore merely another name for) the neurological
disease ME, while chronic fatigue is assigned a different category of
illness in the ICD-10 (Psychiatric). This incorrect practice of using the
terms ‘chronic fatigue’ and ‘chronic fatigues syndrome’ interchangeably
and confusingly has a direct relationship to various design flaws in
research and the inadequate or dangerous treatment of and perjorative and
prejudicial attitudes towards ME/CFS sufferers. Sadly, the Viner et al
article is yet another example of this problem.

In this paper Viner and Christie claim that Randomised clinical
trials in adults have shown that cognitive behaviour therapy and graded
exercise programmes are helpful in most patients. This implies that ME/CFS
sufferers are to be treated in such a way.

As the RCT’s themselves are very small in number, and most research
in this area has been criticised for the high drop out rate of patient
samples, and the patients excluded from such trials (Carruthers et al,
2003, Kennedy and Bryant, 2004). In promoting GET or GAT for ME/CFS,
proponents of the psychiatric paradigm continue to ignore the documented
harmful effects and therefore potential dangers of ‘Graded
Exercise/’Activity’ for ME/CFS sufferers, for example as demonstrated in
Van de Sande (2004) Carruthers et al (2003) 25% Group (2004) Shepherd
(2001) Action for ME (2001), as well as the documented bio-medical
evidence of, for example, specific cardiac problems in ME/CFS sufferers
that provide explanations regarding the post-exertional malaise that leads
to such risks (for example, Peckerman et al, 2003). In this context, the
claims made by Viner and Christie are untenable. They are also potentially
dangerous. At the very least this article should have included an
acknowledgement of such risks, for doctors’ protection as practitioners as
well as patients’ health.

Furthermore, proponents of the psychiatric paradigm of ME/CFS promote
the use of Cognitive Behavioural Therapy, NOT as a strategy of coping with
one’s illness, but as a ‘cure’ for ME/CFS, (which, it must be remembered,
has been both classified and consistently demonstrated as a neurological
illness) believing that the multi-system physiological abnormalities
(manifesting as symptoms) can be improved to the point of ‘recovery’,
merely by challenging the illness beliefs and behaviour of the sufferer
(see for example, Sharpe,1996: 248, Stulemeijer et al, 2004). Their
rationale for the use of CBT is as a ’cure’ for a neurological illness
that they do not even recognise, an illogical position unheard of in
regard to medical approaches to any other neurological or other organic

Viner and Christie therefore appear to be promoting CBT/GET as
treatments that will improve ME/CFS sufferers, without considering the
evidence showing the major problems of such an approach.

In her Rapid Response, Duprey believes kudos is due to Viner and
Christie for ‘spotlighting critical differences in the study of “chronic
fatigue syndrome” versus the much broader category of “fatigue disorders”
thus providing a forum for further clarification and progress‘. Sadly,
there is little evidence of this at all in this article. The major
problem with this article, and one which causes enormous risks to patients
and serious problems to doctors looking for guidance to treat such
patients, is the continued failure to delineate adequately the difference
between ME/CFS and idiopathic chronic fatigue, ie, the failure to discuss
the problem of differential diagnosis. As this issue is well represented
in the literature, a peer review process should have identified this
problem, and Viner and Christie themselves should not be ignoring the
literature on this issue in the first place. Where was their
acknowledgement of the Canadian ME/CFS Case Definition and Treatment
protocols (Carruthers et al, 2003)? Where was their acknowledgement of the
Jason et article showing how the Canadian Guidelines can improve the
differential diagnosis of ME/CFS against other forms of ‘chronic fatigue’?
At the very least one would have expected a nod to these important
references in an overview article.

This continued lack of understanding of the neurological illness
ME/CFS is fast becoming inexcusable among those claiming expertise in
‘chronic fatigue syndrome’, and represents a severe abrogation of duty to
such patients. Both patients, and doctors seeking guidance on how to care
for such patients, deserve better.


25% ME Group, 'Severely Affected ME (Myalgic Encephalomyelitis)
Analysis Report on Questionnaire issued January 2004'‘ March 2004.

Action for ME, “Severely Neglected - M.E. in the UK” (2001).

Carruthers, B. et al (2003) “Myalgic Encephalomyelitis/Chronic
Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and
Treatment Protocols” Journal of Chronic Fatigue Syndrome, Vol. 11(1), pp 7
- 115.
Hooper, M. et al “The Mental Health Movement: Persecution of Patients?”
(2004) Available on the One Click Website:

Hyde, B. Bastien, S. Jain, A. The Clinical and Scientific Basis of
ME/CFS (1992) Nightingale Research Foundation, Canada.

Hyde, B, Jain, A. ‘Clinical Observations of Central Nervous System
Dysfunction in Post-Infectious, Acute Onset, ME/CFS’ in Hyde et al, 1992.

Hyde, B. ‘The Complexities of Diagnosis’ in Jason et al (2003) the
Handbook of Chronic Fatigue Syndrome, Wiley and Sons, New Jersey.

Jason L.A. Torres-Harding S.R. Jurgens, A. Helgerson, J. "Comparing
the Fukuda et al. Criteria and the Canadian Case Definition for
Chronic Fatigue Syndrome". Journal of Chronic Fatigue Syndrome 12(1):37-
52, 2004.

(a) Kennedy A. ‘When Doctors say ‘psychosomatic‘, what do they mean?’
April 2004. Published in Quest (Newsletter of the National ME/FM Action
Network) number 66, Fall 2004. Also available on the One Click Group
Website (ME/CFS Documents)

ME/CFS. Available on the One Click Group Website:

Kennedy, A. Bryant, J. ‘A Summary of the Inherent Theoretical,
and Ethical Flaws in the PACE Trial’ 21 October 2004. Available on the One
Click Website Home page

Marshall, E. Williams, M. ’Denigration by Design? A Review, with
References, of the Role of Dr Simon Wessely in the Perception of Myalgic
Encephalomyelitis, 1987 - 1996‘ September 1996, and Marshall, E. Williams,
M. ‘Denigration by Design: 1999 Update’ 1999. Available at:

Peckerman A, LaManca JJ, Dahl KA, Chemitiganti R, Qureishi B,
Natelson BH. "Abnormal impedance cardiography predicts symptom severity in
chronic fatigue syndrome." The American Journal of the Medical Sciences:
Arnold Peckerman, Rahul Chemitiganti, Caixia Zhao, Kristina Dahl, Benjamin
H. Natelson, Lionel Zuckier, Nasrin Ghesani, Samuel Wang, Karen Quigley
and S. Sultan Ahmed. "Left Ventricular Function in Chronic Fatigue
Syndrome (CFS): Data From Nuclear Ventriculography Studiesof Response to
Exercise and Postural Stress," Findings presented at the American
Physiological Society conference, Experimental Biology 2003, April 11-15,
2003, San Diego Convention Center, San Diego, CA

Sharpe, M. C. in Demitrack, M.A. Abbey, S. E (eds.) Chronic Fatigue
Syndrome (1996) Guildford Press, New York.
Shepherd C. Pacing and exercise in chronic fatigue syndrome. Physiother
2001 Aug;87(8):395-396.

Stulemeijer, M. de Jong, L.W.A.M. Fiselier, T.J.W. Hoogveld, SW.B.
Bleijenberg, G. 'Cognitive Behaviour Therapy for Adolescents with Chronic
Fatigue syndrome: A Randomised Controlled Trial‘ (online) 7th
December 2004.

Van De Sande, M. ‘ME/CFS Post-Exertional Malaise / Fatigue and
Exercise’ Quest (Newsletter of the National ME/FM Action Network) #60,
June/July, 2003. Also available on:

Wessely , S. "Microbes, Mental Illness, the Media and ME: the
Construction of Disease" Eliot Slater Memorial Lecture, 12 May 1994.
Available with comment by Margaret Williams:

Angela Kennedy
The One Click Group

Competing interests:
Carer of young woman with ME/CFS; Social Sciences lecturer and researcher; Director of the One Click Group, a political pressure group advocacting for people with ME/CFS.

Competing interests: No competing interests

03 May 2005
Angela P. Kennedy
Social Sciences Lecturer
Essex IG8