Intended for healthcare professionals

Rapid response to:


Hypocalcaemia after intravenous bisphosphonate

BMJ 2004; 328 doi: (Published 10 June 2004) Cite this as: BMJ 2004;328:1439

Rapid Response:

Bisphosphonates in metastatic cancer

I think this is a suitable setting to ask a basic question about the
use of bisphosphonates in patients with bone metastases.
Several studies reported an improvement in "skeletal related events" (SRE)
in patients treated with bisphophonates, but I find it quite peculiar that
SRE include not only complications such as fractures, but also further
treatments such as radiotherapy to the bones (see for example the paper by
Rosen et Al. in J Clin Oncol 2003, 21:3150).
Is it correct to consider together a complication of disease and its

Competing interests:
None declared

Competing interests: No competing interests

12 June 2004
Giovanni Codacci-Pisanelli
Research Assistant
Univ. of Rome