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Relation of childhood gastrointestinal disorders to autism: nested case-control study using data from the UK General Practice Research Database

BMJ 2002; 325 doi: https://doi.org/10.1136/bmj.325.7361.419 (Published 24 August 2002) Cite this as: BMJ 2002;325:419

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AUTISM - AN IMMUNE COMPLEX DISORDER FOLLOWING MMR?

Editor,

Richard G Fiddian-Green points out that the only significant finding
in Wakefield's original report, was raised urinary methylmalonic acidosis
(P=0.003).

The most common cause of a raised urinary methylmalonic acid is
Vitamin B12 deficiency [1]. In a child, on a normal diet containing animal
protein, the most common cause of a Vitamin B12 deficiency is a disease of
the ileum[2].

Both these observations are consistent with the Wakefield hypothesis.

”There exists a subset of children who are vulnerable to developing a
particular form of regressive autism following previously normal
development in combination with a novel form of inflammatory bowel
disease. Onset may
occur over weeks or sometimes months, and is triggered by exposure to a
measles containing vaccine, predominantly the measles mumps rubella
vaccine (MMR), that is in use in much of the world today. This exposure
leads to long term infection with measles virus within key sites,
including the intestine where it causes inflammation.”[3]

The inflammatory bowel (ileal) lesion and the consequent increase in
urinary methylmalonic acid can both be the result of an Immune Complex
Disorder induced by an antigen excess as may occur in MMR vaccination.

Perhaps one should be looking for evidence of Immune Complexes, both
soluble circulating complexes, and fixed in Tissue Immune Complexes. It
may also be worthwhile estimating the level of Serum Vitamin B12 if these
tests have not already been done.

Michael D Innis FRCPA; FRCPath

References

1.The Laboratory in Clinical Medicine . Interpretation and
Application p 488 Edited by Halsted JA Published by W.B.Saunders Company.
Philadelphia, London, Toronto 1976

2.The Laboratory in Clinical Medicine . Interpretation and
Application p 486 Edited by Halsted JA Published by W.B.Saunders Company.
Philadelphia, London, Toronto 1976

3.http://www.whale.to/vaccines/wakefield.html [September 2004]

Competing interests:
None declared

Competing interests: No competing interests

04 November 2004
Michael D Innis
Director Medisets International
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