Analytical problems (not only) with BNP determining
No international consensus exists yet on the methods for assessing diagnostic tests and it may be a serious problem. As I recently stated here (1), analytical problems with BNP determination are discussed in the literature. Analytical problems are hot topics in all new diagnostics. The more different diagnostics, the more analytical bias (2), and the more difficult establishing the normal range and determining the diagnostic accuracy. Better assay harmonisation could improve practice. Phase I in architecture of diagnostic research thus should be the key phase.
1. Gasko R. Analytical problems with BNP determining. Rapid response to: Doust JA, Pietrzak E, Dobson A, Glasziou P. How well does B-type natriuretic peptide predict death and cardiac events in patients with heart failure: systematic review. BMJ 2005;330:625-634.
2. Steele BW, Wang E, Klee GG, Thienpont LM, Soldin SJ, Sokoll LJ et al. Analytic Bias of Thyroid Function Tests: Analysis of a College of American Pathologists Fresh Frozen Serum Pool by 3900 Clinical Laboratories. Arch Pathol Lab Med 2005;129:310-317.
Competing interests: None declared
Competing interests: No competing interests