alarm over animal models
"Animal models of genetic diseases are proving useful research
The reasons why this statement alarms me relate to the fact that we are in
no way physically related to research animals.
The mechanisms of meiotic cell division which underlie gametogenesis and
therefore sexual reproduction serve to FIX the CHROMOSOME NUMBERS of
species .Because synapsis/meiosis will not occur unless each chromosome
has an homologous partner.And the respective members of each chromosome
pair are inherited from the respective male and female parents.So there is
no way an ODDly inherited chromosome can be bequeathed to the next
SECONDLY, the known chromosome numbers of various species ARE NOT RANKED
IN ANY SORT OF HIERARCHICAL ORDER-i.e.
THERE IS NO "EVOLUTIONARY"ORDER in chromosome numbers.See
Therefore we are not physically related to laboratory animals in any
way,and therefore any similarities between our respective
physiological/pathological responses to various experimental insults are
inferences from animal experiments must remain purely conjectural.
One set of tragic consequences resulting from extrapolation of animal
findings to humans is recorded in BMJ25/4/98pp
1295-1298"Recent experience with fialuridin.....5ouf of15 patients
died,2required...............this effect had not been demonstrated in FOUR
I would like to suggest that our thinking will become clearer when we have
debunked the theory of evolution.
And the marvels which you have revealed will become all the more
Competing interests: No competing interests