Intended for healthcare professionals

Rapid response to:


Cost effectiveness of ward based non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease: economic analysis of randomised controlled trial

BMJ 2003; 326 doi: (Published 03 May 2003) Cite this as: BMJ 2003;326:956

Rapid Response:

Transenteral and peritoneal oxygenation

We have shown in pigs that delivering oxygen through the lumen of
some two thirds of the small intestine prevented the compensatory increase
in cardiac output in experimentally induced severe hypoxaemia (1). Judging
from the magnitude of the reduction in cardiac output achieved the amount
of oxygen delivered was equal to about 25% of that delivered in blood in
normoxia. The transenteric delivery of oxygen, and removal of CO2, was
accomapnied by a rise in both portal venous and systemic pO2.

Shozo Baba, professor of surgery at Hammamatsu in Japan, has obtained
similar results with a small animal model using intraperitoneal infusions
of oxygenated perflurocarbonemulsions. These emulsions are safe, having
been successfully used for transbronchial oxygenation and coronary artery

I have proposed to clinical investigators in India and South Africa
that enteric lavage with oxygenated perfluorocarbon emulsions might
provide a simple, safe and cost-effective method for oxygenating patients
in lesser developed countries.

1. Gross BD, Sacristan E, Peura RA, Shahnarian A, Devereaux D, Wang
HL, Fiddian-Green R. Supplemental systemic oxygen support using an
intestinal intraluminal membrane oxygenator. Artif Organs. 2000

Competing interests:  
None declared

Competing interests: No competing interests

09 May 2003
Richard G Fiddian-Green