Intended for healthcare professionals

Rapid response to:

Clinical Review ABC of clinical electrocardiography

Myocardial ischaemia

BMJ 2002; 324 doi: https://doi.org/10.1136/bmj.324.7344.1023 (Published 27 April 2002) Cite this as: BMJ 2002;324:1023

Rapid Response:

Re: wellen's syndrome?

WELLENS’ SYNDROME

A. Definition – EKG pattern of T waves in the precordial leads that are associated with a critical stenosis of the proximal left anterior descending coronary artery

B. Simplified criteria for Wellens’ Syndrome

Prior history of chest pain

Little or no cardiac enzyme elevation.

No pathologic precordial Q waves.

Little or no ST-segment elevation.

No loss of precordial R waves.

Biphasic T waves in leads V2 and V3 (Type 1) or symmetric, often deeply inverted T waves in leads V2 and V3 (Type 2).

NOTE: these EKG changes usually occur during a pain-free interval when other evidence of ischemia or unstable angina may be absent.

C. What is important about Wellens’ Syndrome?

It is highly specific for left anterior descending coronary artery lesions.

These patients are at risk for an extensive anterior wall myocardial infarction and/or sudden death.

Early cardiac catheterization with subsequent angioplasty or CABG is now recommended for these patients.

D. Pitfalls

Diagnosing the biphasic T-wave pattern as "nonspecific" EKG changes, which they are not.

Diagnosing the EKG changes as nontransmural or subendocardial ischemia/infarction and treating them with conservative therapy.

In ER’s with chest pain centers, placing these patients in the "nonspecific" EKG protocol and doing an exercise stress test on them. Exercise stress tests are contraindicated in the presence of suspected left main lesions.

Reference: Wellens’ Syndrome, Annals of Emergency Medicine, March 1999, Vol.33, No. 3, pp347-351.

Competing interests: No competing interests

30 April 2002
Pankaj Dubey
Registrar in Medicine
Perth,Western Australia
Sir Charles Gairdner Hospital