Intended for healthcare professionals

Rapid response to:


Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis

BMJ 2003; 326 doi: (Published 26 June 2003) Cite this as: BMJ 2003;326:1423

Rapid Response:

the paradox of cholesterol and stroke

The authors state that there is a paradox in that the use of statins
has been shown to reduce the incidence of stroke, but that studies show no
association with cholesterol concentration and stroke. May this not be due
to the fact that statins work not because they lower cholesterol, but
because they do something else, something we may not know about yet. I
speak as a sceptic about the cholesterol hypothesis, but one willing to
accept that statins work for whatever reason, and it seems to me that the
evidence increasingly points to the fact that the treatment is statins
even if we don't quite know the diagnosis or its cause.

Competing interests:  
None declared

Competing interests: No competing interests

29 June 2003
Mark J Boulter
llanfair surgery llandovery SA20 0NG