Evidence b(i)ased medicine—selective reporting from studies sponsored by pharmaceutical industry: review of studies in new drug applications

Editors,
A 46 year-long clinical experience allows me to state that the authors are
right stating “any attempt to recommend a specific selective serotonin
reuptake inhibitor from the publicly available data only is likely to be
based on biased evidence” (1). As a matter of fact, in the course of
efficacious therapy with selective serotonin reuptake inhibitors, both
neuronal and cerebral evoked potentials, now-a-days assessed at the bed-
side with the aid of Biophysical Semeiotics in reliable way (2, 3; and
HONCode site 233736, http://digilander.libero.it/semeioticabiofisica) ,
ameliorate clearly. In addition, under identical condition, cerebral
microcirculatory functional reserve improves statistically (3, 4).
Unfortunately, pharmaceutical descriptions of drug significant effects
often do not parallels the reality. Finally, no pharmaceutical companies
have published an only critical paper of mine.
God thanks, doctor can utilize EBM as well as SPBM, i.e. "Single Patient
Based Medicine".

1) Melander H., Ahlqvist-Rastad J. et al. Evidence b(i)ased
medicine—selective reporting from studies sponsored by pharmaceutical
industry: review of studies in new drug applications. BMJ 2003;326:1171
-1173 (31 May)
2) Stagnaro S., Percussione Ascoltata degli Attacchi Ischemici Transitori.
Ruolo dei Potenziali Cerebrali Evocati. Min. Med. 76, 1211 (Pub-Med
indexed for Medline) 1985.
3) Stagnaro S., Valutazione percusso-ascoltatoria della microcircolazione
cerebrale globale e regionale. Atti, XII Congr. Naz. Soc. It. di
Microangiologia e Microcircolazione. 13-15 Ottobre, Salerno, e Acta Medit.
145, 163, 1986).
4) Stagnaro-Neri M., Stagnaro S., Diagnosi precoce dell’invecchiamento
cerebrale con la percussione ascoltata. Monitoraggio terapeutico con la
Nicergolina. Ricerca Med. 6, 348,1989

Competing interests:  
None declared