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Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study

BMJ 1999; 319 doi: (Published 23 October 1999) Cite this as: BMJ 1999;319:1106

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Deprivation may be a confounding variable.


Abajo et. al. raise an interesting association between selective
serotonin reuptake inhibitors and upper gastrointestinal haemorrhage.
However, they do not state how they selected randomised controls. They
have not analysed for the effect of socioeconomic deprivation, which may
account for a large part of the association they describe. (1)

Given that there is a clustering of depression in areas of
socioeconomic deprivation, we wonder if they may be able to further
examine their data to determine if this is a confounding variable.


Dr. Mary Blatchford.

Senior Tutor

Department of General Practice,
Glasgow University.

Dr. Laura Macdonald

General Practice Registrar

Easterhouse Health Centre,
9 Auchinlea Road,
Glasgow G34 9HQ.

(1) Acute Upper Gastrointestinal Haemorrage in the West of Scotland:
case ascertainment study. Blatchford o, Davidson LA, Murray WR, Blatchford
M, Pell H. BMJ 1997: 315: 510-514.

No conflict of interest.

Competing interests: No competing interests

24 November 1999
Mary Blatchford
senior tutor, Department of General Practice.
University of Glasgow