Abstract
Serologic reactivities of serum or plasma from 55 HIV-1 subjects in four countries--Brazil, Rwanda, Thailand, and Uganda--were examined by V3 peptide immunoassay. Forty-seven (85.5%) of the 55 specimens tested positive to the homologous peptide. A strong correlation between serotype (i.e., pattern of serologic reactivity with a panel of peptides) and genotype was not found. However, the V3 peptide immunoassays may be useful for epidemiologic studies to trace the distinctive HIV-1 strains from different geographic regions of the world. The serology data obtained may be useful for the development of effective V3-based vaccines.
MeSH terms
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AIDS Vaccines / pharmacology
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Amino Acid Sequence
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Antigenic Variation*
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Brazil / epidemiology
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Cluster Analysis
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HIV Envelope Protein gp120 / genetics
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HIV Envelope Protein gp120 / immunology
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HIV Infections / epidemiology
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HIV Infections / virology
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HIV-1 / classification
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HIV-1 / genetics*
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HIV-1 / immunology*
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Humans
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Immunoenzyme Techniques
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Molecular Sequence Data
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Peptide Fragments / genetics
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Peptide Fragments / immunology
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Peptides / genetics
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Peptides / immunology
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Rwanda / epidemiology
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Seroepidemiologic Studies
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Serotyping
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Thailand / epidemiology
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Uganda / epidemiology
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World Health Organization
Substances
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AIDS Vaccines
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HIV Envelope Protein gp120
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HIV envelope protein gp120 (305-321)
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Peptide Fragments
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Peptides