Lymphoma risk in coeliac disease of later life

Digestion. 1982;23(2):89-92. doi: 10.1159/000198692.

Abstract

From 314 patients with coeliac disease, 20 patients were found to have developed a lymphoma. The incidence of lymphoma was much greater in the 6th, 7th and 8th decades of life than in the previous two decades. In 12 patients, the lymphoma was diagnosed within 4 years of the diagnosis of their coeliac disease and there were significantly more of these lymphomas appearing in coeliacs diagnosed between 51 and 80 years, who made up 23% of the series, than in those diagnosed between 21 and 50 years. We conclude that lymphoma is particularly a complication of older coeliacs and that coeliacs newly diagnosed at more than 50 years of age should be more closely followed up for they have a 1 in 10 chance of harbouring a lymphoma.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Celiac Disease / complications*
  • Female
  • Humans
  • Intestinal Neoplasms / etiology*
  • Lymphoma / etiology*
  • Male
  • Middle Aged
  • Risk