Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfers in high responders

Bruce S Shapiro; Said T Daneshmand; Forest C Garner; Martha Aguirre; Cynthia Hudson; Shyni Thomas

doi:10.1016/j.fertnstert.2011.02.059

Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfers in high responders

Fertil Steril. 2011 Aug;96(2):516-8. doi: 10.1016/j.fertnstert.2011.02.059. Epub 2011 Jul 6.

Authors

Bruce S Shapiro¹, Said T Daneshmand, Forest C Garner, Martha Aguirre, Cynthia Hudson, Shyni Thomas

Affiliation

¹ Fertility Center of Las Vegas, Las Vegas, Nevada 89117, USA. bsshapiro@aol.com

PMID: 21737071
DOI: 10.1016/j.fertnstert.2011.02.059

Abstract

Clinical pregnancy rates of 80% and 65% were observed in cycles using thawed and fresh embryos, respectively, although embryo quality indicators revealed morphologically and numerically inferior embryo cohorts after cryopreservation. Subsequent logistic regression analysis controlled for differences in embryo quality and revealed significantly greater probability of clinical pregnancy with thawed embryos when compared with fresh, suggesting a negative effect of ovarian stimulation on endometrial receptivity.

Trial registration: ClinicalTrials.gov NCT00963079.

Publication types

Comparative Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Blastocyst*
Cryopreservation*
Embryo Implantation*
Embryo Transfer* / adverse effects
Endometrium / physiopathology*
Female
Fertilization in Vitro* / adverse effects
Humans
Infertility / physiopathology
Infertility / therapy*
Logistic Models
Nevada
Ovulation Induction* / adverse effects
Pregnancy
Pregnancy Rate
Prospective Studies
Treatment Outcome

Associated data

ClinicalTrials.gov/NCT00963079