Abstract
Two new vaccines have recently been shown to be safe and effective in protecting young children against severe rotavirus gastroenteritis. Although both vaccines are now marketed worldwide, it is likely that improvements to these vaccines and/or the development of future generations of rotavirus vaccines will be desirable. This Review addresses recent advances in our knowledge of rotavirus, the host immune response to rotavirus infection and the efficacy and safety of the new vaccines that will be helpful for improving the existing rotavirus vaccines, or developing new rotavirus vaccines in the future.
MeSH terms
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Animals
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Antibodies, Viral / blood
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Cattle
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Female
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Gastroenteritis / immunology
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Gastroenteritis / prevention & control*
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Gastroenteritis / virology
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Humans
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Infant
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Mice
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Rabbits
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Rotavirus / genetics
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Rotavirus / immunology
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Rotavirus / physiology*
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Rotavirus Infections / immunology
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Rotavirus Infections / prevention & control*
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Rotavirus Infections / virology
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Rotavirus Vaccines* / administration & dosage
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Rotavirus Vaccines* / adverse effects
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Rotavirus Vaccines* / immunology
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Treatment Outcome
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Vaccines, Attenuated / administration & dosage
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Vaccines, Attenuated / adverse effects
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Vaccines, Attenuated / immunology
Substances
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Antibodies, Viral
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RotaTeq
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Rotavirus Vaccines
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Vaccines, Attenuated
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rhesus rotavirus vaccine