Abstract
The combination of 2 mg cyproterone acetate, a pronounced antiandrogenic substance, in combination with 0.05 mg ethinyl estradiol has undergone intensive multiphasic clinical evaluation. The preparation with the trade name Diane has proven to be not only a reliable contraceptive, but also a very potent drug for the treatment of both acne and seborrhea, and of milder cases of hirsutism. The effect of Diane on markedly increased hair growth was not so pronounced. In addition to the presentation of the most pertinent steps of the clinical investigation of Diane, the possible mode of actions of antiandrogens alone and in combination with an estrogen is discussed.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
MeSH terms
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Acne Vulgaris / drug therapy
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Adolescent
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Adult
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Chemical Phenomena
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Chemistry
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Clinical Trials as Topic
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Contraceptives, Oral / pharmacology*
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Contraceptives, Oral, Combined / pharmacology*
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Cyproterone / pharmacology*
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Cyproterone / therapeutic use
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Cytosol / metabolism
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Dermatitis, Seborrheic / drug therapy
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Double-Blind Method
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Drug Combinations
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Drug Evaluation
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Ethinyl Estradiol / pharmacology*
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Ethinyl Estradiol / therapeutic use
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Female
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Hirsutism / drug therapy
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Humans
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Norgestrel / analogs & derivatives
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Norgestrel / pharmacology
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Norgestrel / therapeutic use
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Ovulation / drug effects*
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Pregnancy
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Random Allocation
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Receptors, Progesterone / metabolism
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Testosterone / metabolism
Substances
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Contraceptives, Oral
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Contraceptives, Oral, Combined
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Drug Combinations
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Receptors, Progesterone
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Norgestrel
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Testosterone
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Ethinyl Estradiol
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Cyproterone