This updated guidance from the Advisory Committee on Malaria Prevention for UK Travellers provides the essential information for healthcare workers who advise travellers. The many personal, visit and location-specific factors that need to be taken into account are discussed. Tables include the available antimalarials for prophylaxis and for standby treatment, appropriate choices of regimen by region and country for malarious areas, and the adjustments needed for children and in concomitant disease. There is greater emphasis on mefloquine, doxycycline and atovaquone/proguanil as the three options for highly chloroquine-resistant falciparum malarious areas, and changes in emergency standby medication.