Abstract
Acute organophosphorus (OP) poisoning is usually treated with atropine plus cholinesterase reactivators such as oximes, but controlled trials to assess the efficacy of oximes in OP poisoning have not been done. A period when the acetyl cholinesterase reactivator pralidoxime chloride was not available in Sri Lanka gave us the opportunity to compare atropine alone for treatment of moderate to severe OP poisoning (21 patients) with atropine plus pralixodime (24 patients). Outcome, as assessed clinically, was similar in the two groups. These results cast doubt on the necessity of cholinesterase reactivators for treatment of acute OP poisoning.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
MeSH terms
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Adolescent
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Adult
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Aged
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Atropine / administration & dosage
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Atropine / therapeutic use*
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Cholinesterase Reactivators / administration & dosage
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Cholinesterase Reactivators / pharmacology
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Cholinesterase Reactivators / therapeutic use*
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Critical Care / statistics & numerical data
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Drug Therapy, Combination
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Female
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Humans
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Length of Stay / statistics & numerical data
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Male
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Middle Aged
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Organophosphate Poisoning*
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Poisoning / drug therapy*
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Poisoning / epidemiology
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Poisoning / mortality
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Pralidoxime Compounds / administration & dosage
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Pralidoxime Compounds / pharmacology
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Pralidoxime Compounds / therapeutic use*
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Sri Lanka / epidemiology
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Treatment Outcome
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Ventilators, Mechanical / statistics & numerical data
Substances
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Cholinesterase Reactivators
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Pralidoxime Compounds
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Atropine
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pralidoxime