Chest
Original ResearchCOPDSystemic Inflammation and COPD: The Framingham Heart Study
Section snippets
Subjects, Covariates, and Measures of Pulmonary Function and Systemic Inflammation
Participants attending the most recent completed examination (ie, seventh, from 1998 to 2001) of the Offspring Cohort4 were eligible for inclusion. Informed consent was obtained in accordance with the protocol approved by the Institutional Review Board of Boston University Medical Center. The single-day examination included a variety of procedures, with phlebotomy after an overnight fast (typically between 8:00 am and 9:00 am) and subsequent spirometry without bronchodilator testing performed
Subject Characteristics
Participant characteristics are described in Table 1; the majority were female and had a history of cigarette smoking. Compared to those without evidence of chronic airflow obstruction, those with COPD were older, were more likely to be smokers, and had more pack-years of smoking exposure. Such differences between subjects with and without COPD also existed among the subgroup with at least 10 pack-years of cigarette smoking. Additionally, subjects with COPD generally had higher concentrations
Discussion
We observed significant cross-sectional associations between a number of the biomarkers of systemic inflammation and impaired lung function. Although there appeared to be some differences in the associations with impaired lung function between the smoking strata, in our exploratory analyses these differences were statistically significant only for the relation of CD40L to COPD.
CRP may have direct immunomodulatory effects in the lung1314151617 and has been previously associated with impaired
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Support was provided by National Institutes of Health/National Heart, Lung, and Blood Institute contracts N01-HC-25195, N01-HV-28178, HL076784, HL064753, and AG028321. Drs. Walter and Wilk are each recipients of a Young Clinical Scientist Award from the Flight Attendant Medical Research Institute.
The authors have no conflicts of interests to disclose.