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Guidelines for the Prevention of Intravascular Catheter–Related Infections

Published online by Cambridge University Press:  02 January 2015

Naomi P. O'Grady
Affiliation:
Clinical Center, National Institutes of Health, Bethesda, Maryland Society of Critical Care Medicine (SCCM)
Mary Alexander
Affiliation:
Infusion Nurses Society (INS), Cambridge, Massachusetts
E. Patchen Dellinger
Affiliation:
Department of Surgery, University of Washington, Seattle, Washington, representing the Surgical Infection Society (SIS) and SCCM
Julie L. Gerberding
Affiliation:
Division of Healthcare Quality Promotion, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia
Stephen O. Heard
Affiliation:
Department of Anesthesiology, University of Massachusetts Medical School, Worcester, Massachusetts, representing the American College of Chest Physicians (ACCP) and the American Society of Critical Care Anesthesiologists (ASCCA)
Dennis G. Maki
Affiliation:
Infectious Diseases Section, University of Wisconsin Medical School, Madison, Wisconsin
Henry Masur
Affiliation:
Clinical Center, National Institutes of Health, Bethesda, Maryland Infectious Diseases Society of America (IDSA)
Rita D. McCormick
Affiliation:
University of Wisconsin Hospital and Clinics, Madison, Wisconsin, representing the Association for Professionals in Infection Control and Epidemiology (APIC)
Leonard A. Mermel
Affiliation:
Division of Infectious Diseases, Rhode Island Hospital, andBrown University School of Medicine, Providence, Rhode Island
Michele L. Pearson
Affiliation:
Division of Healthcare Quality Promotion, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia
Issam I. Raad
Affiliation:
Department of Medical Specialties, MD Anderson Cancer Center, Houston, Texas
Adrienne Randolph
Affiliation:
Departments of Anesthesia and Pediatrics, Children's Hospital, Boston, Massachusetts
Robert A. Weinstein
Affiliation:
Division of Infectious Disease, Cook County Hospital and Rush Medical College, Chicago, Illinois, representing the Society for Healthcare Epidemiology of America (SHEA)

Abstract

Background:

Although many catheter-related blood-stream infections (CRBSIs) are preventable, measures to reduce these infections are not uniformly implemented.

Objective:

To update an existing evidenced-based guideline that promotes strategies to prevent CRBSIs.

Data Sources:

The MEDLINE database, conference proceedings, and bibliographies of review articles and book chapters were searched for relevant articles.

Studies Included:

Laboratory-based studies, controlled clinical trials, prospective interventional trials, and epidemiologic investigations.

Outcome Measures:

Reduction in CRBSI, catheter colonization, or catheter-related infection.

Synthesis:

The recommended preventive strategies with the strongest supportive evidence are education and training of healthcare providers who insert and maintain catheters; maximal sterile barrier precautions during central venous catheter insertion; use of a 2% chlorhexidine preparation for skin antisepsis; no routine replacement of central venous catheters for prevention of infection; and use of antiseptic/antibiotic-impregnated short-term central venous catheters if the rate of infection is high despite adherence to other strategies (ie, education and training, maximal sterile barrier precautions, and 2% chlorhexidine for skin antisepsis).

Conclusion:

Successful implementation of these evidence-based interventions can reduce the risk for serious catheter-related infection.

Type
Special Report
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2002

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References

1.Sherertz, RJ, Ely, EW, Westbrook, DM, et al. Education of physicians-in-training can decrease the risk for vascular catheter infection. Ann Intern Med 2000;132:641648.CrossRefGoogle ScholarPubMed
2.Eggimann, P, Harbarth, S, Constantin, MN, Touveneau, S, Chevrolet, JC, Pittet, D. Impact of a prevention strategy targeted at vascular-access care on incidence of infections acquired in intensive care. Lancet 2000;355:18641868.CrossRefGoogle ScholarPubMed
3.Nehme, AE. Nutritional support of the hospitalized patient: the team concept. JAMA 1980;243:19061908.Google Scholar
4.Soifer, NE, Borzak, S, Edlin, BR, Weinstein, RA. Prevention of peripheral venous catheter complications with an intravenous therapy team: a randomized controlled trial. Arch Intern Med 1998;158:473477.CrossRefGoogle ScholarPubMed
5.Tomford, JW, Hershey, CO. The i.v. therapy team: impact on patient care and costs of hospitalization. NITA 1985;8:387389.Google ScholarPubMed
6.Davis, D, O'Brien, MA, Freemantle, N, Wolf, FM, Mazmanian, P, Taylor-Vaisey, A. Impact of formal continuing medical education: do conferences, workshops, rounds, and other traditional continuing education activities change physician behavior or health care outcomes? JAMA 1999;282:867874.CrossRefGoogle ScholarPubMed
7.Conly, JM, Hill, S, Ross, J, Lertzman, J, Louie, TJ. Handwashing practices in an intensive care unit: the effects of an educational program and its relationship to infection rates. Am J Infect Control 1989;17:330339.CrossRefGoogle Scholar
8.East, SA. Planning, implementation, and evaluation of a successful hospital-based peripherally inserted central catheter program. Journal of Intravenous Nursing 1994;17:189192.Google Scholar
9.Kyle, KS, Myers, JS. Peripherally inserted central catheters: development of a hospital-based program. Journal of Intravenous Nursing 1990;13:287290.Google Scholar
10.BeVier, PA, Rice, CE. Initiating a pediatric peripherally inserted central catheter and midline catheter program. Journal of Intravenous Nursing 1994;17:201205.Google ScholarPubMed
11.Tomford, JW, Hershey, CO, McLaren, CE, Porter, DK, Cohen, DI. Intravenous therapy team and peripheral venous catheter-associated complications: a prospective controlled study. Arch Intern Med 1984; 144:11911194.CrossRefGoogle ScholarPubMed
12.Wenzel, RP, Wentzel, RP. The development of academic programs for quality assessment. Arch Intern Med 1991;151:653654.Google Scholar
13.Fridkin, SK, Pear, SM, Williamson, TH, GaLgiani, JN, Jarvis, WR. The role of understaffing in central venous catheter-associated bloodstream infections. Infect Control Hosp Epidemiol 1996;17:150158.Google Scholar
14.Robert, J, Fridkin, SK, Blumberg, HM, et al. The influence of the composition of the nursing staff on primary bloodstream infection rates in a surgical intensive care unit. Infect Control Hosp Epidemiol 2000;21:1217.Google Scholar
15.Vicca, AF. Nursing staff workload as a determinant of methicillin-resistant Staphylococcus aureus spread in an adult intensive therapy unit. J Hosp Infect 1999;43:109113.CrossRefGoogle Scholar
16.Pearson, ML. Guideline for prevention of intravascular device-related infections: Part I. Intravascular device-related infections: an overview. The Hospital Infection Control Practices Advisory Committee. Am J Infect Control 1996;24:262277.Google Scholar
17.White, MC, Ragland, KE. Surveillance of intravenous catheter-related infections among home care clients. Am J Infect Control 1994;22:231235.Google Scholar
18.Lorenzen, AN, Itkin, DJ. Surveillance of infection in home care. Am J Infect Control 1992;20:326329.Google Scholar
19.White, MC. Infections and infection risks in home care settings. Infect Control Hosp Epidemiol 1992;13:535539.Google Scholar
20.Pittet, D, Tarana, D, Wenzel, RP. Nosocomial bloodstream infection in critically ill patients', excess length of stay, extra costs, and attributable mortality. JAMA 1994;271:15981601.CrossRefGoogle ScholarPubMed
21.Raad, II, Baba, M, Bodey, GP. Diagnosis of catheter-related infections: the role of surveillance and targeted quantitative skin cultures. Clin Infect Dis 1995;20:593597.Google Scholar
22.Widmer, AF, Nettleman, M, Flint, K, Wenzel, RP. The clinical impact of culturing central venous catheters: a prospective study. Arch Intern Med 1992;152:12991302.Google Scholar
23.Larson, EL, Rackoff, WR, Weiman, M, et al. APIC guideline for handwashing and hand antisepsis in health care settings. Am J Infect Control 1995;23:251269.Google Scholar
24.Boyce, JM, Farr, BM, Jarvis, WR, et al. Guideline for hand hygiene in the healthcare setting. Am J Infect Control 2002. In press.Google Scholar
25.Bischoff, WE, Reynolds, TM, Sessler, CN, Edmond, MB, Wenzel, RP. Handwashing compliance by health care workers: the impact of introducing an accessible, alcohol-based hand antiseptic. Arch Intern Med 2000;160:10171021.Google Scholar
26.Pittet, D, Dharan, S, Touveneau, S, Sauvan, V, Perneger, TV. Bacterial contamination of the hands of hospital staff during routine patient care. Arch Intern Med 1999;159:821826.CrossRefGoogle ScholarPubMed
27.Simmons, B, Bryant, J, Neiman, K, Spencer, L, Arheart, K. The role of handwashing in prevention of endemic intensive care unit infections. Infect Control Hosp Epidemiol 1990;11:589594.Google Scholar
28.Boyce, JM, Kelliher, S, Vallande, N. Skin irritation and dryness associated with two hand-hygiene regimens: soap-and-water hand washing versus hand antisepsis with an alcoholic hand gel. Infect Control Hosp Epidemiol 2000;21:442448.CrossRefGoogle ScholarPubMed
29.Mermel, LA, McCormick, RD, Springman, SR, Maki, DG. The pathogenesis and epidemiology of catheter-related infection with pulmonary artery Swan-Ganz catheters: a prospective study utilizing molecular sub-typing. Am J Med 1991;91:197S205S.CrossRefGoogle Scholar
30.Raad, II, Hohn, DC, Gilbreath, BJ, et al. Prevention of central venous catheter-related infections by using maximal sterile barrier precautions during insertion. Infect Control Hosp Epidemiol 1994;15:231238.Google Scholar
31.Capdevila, JA. Catheter-related infection: an update on diagnosis, treatment, and prevention. Int J Infect Dis 1998;2:230236.Google Scholar
32.Abi-Said, D, Raad, I, Umphrey, J, et al. Infusion therapy team and dressing changes of central venous catheters. Infect Control Hosp Epidemiol 1999; 20:101105.Google Scholar
33.Centers for Disease Control. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in health-care settings. MMWR 1988;24:377382.Google Scholar
34.Povoski, SP. A prospective analysis of the cephalic vein cutdown approach for chronic indwelling central venous access in 100 consecutive cancer patients. Ann Surg Oncol 2000;7:496502.CrossRefGoogle ScholarPubMed
35.Arrighi, DA, Farnell, MB, Mucha, P Jr, Iistrup, DM, Anderson, DL. Prospective, randomized trial of rapid venous access for patients in hypovolemic shock. Ann Emerg Med 1989;18:927930.Google Scholar
36.Ahmed, Z, Mohyuddin, Z. Complications associated with different insertion techniques for Hickman catheters. Postgrad Med J 1998;74:104107.Google Scholar
37.Maki, DG, Ringer, M, Alvarado, CJ. Prospective randomised trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. Lancet 1991;338:339343.Google Scholar
38.Garland, JS, Buck, RK, Maloney, Ret al. Comparison of 10% povidone-iodine and 0.5% chlorhexidine gluconate for the prevention of peripheral intravenous catheter colonization in neonates: a prospective trial. Pediatr Infect Dis J 1995;14:510516.Google Scholar
39.Little, JR, Murray, PR, Traynor, PS, Spitznagel, E. A randomized trial of povidone-iodine compared with iodine tincture for venipuncture site disinfection: effects on rates of blood culture contamination. Am J Med 1999;107:119125.Google Scholar
40.Mimoz, O, Pieroni, L, Lawrence, C, et al. Prospective, randomized trial of two antiseptic solutions for prevention of central venous or arterial catheter colonization and infection in intensive care unit patients. Crit Care Med 1996;24:18181823.Google Scholar
41.Maki, DG, McCormack, KN. Defatting catheter insertion sites in total parenteral nutrition is of no value as an infection control measure: controlled clinical trial. Am J Med 1987;83:833840.Google Scholar
42.Maki, DG, Stolz, SS, Wheeler, S, Mermel, LA. A prospective, randomized trial of gauze and two polyurethane dressings for site care of pulmonary artery catheters: implications for catheter management. Crit Care Med 1994;22:17291737.Google Scholar
43.Bijma, R, Girbes, AR, Kleijer, DJ, Zwaveling, JH. Preventing central venous catheter-related infection in a surgical intensive-care unit. Infect Control Hosp Epidemiol 1999;20:618620.Google Scholar
44.Rasero, L, Degl'Innocenti, M, Mocali, M, et al. Comparison of two different time interval protocols for central venous catheter dressing in bone marrow transplant patients: results of a randomized, multicenter study. Haematologica 2000;85:275279.Google Scholar
45.Madeo, M, Martin, CR, Turner, C, Kirkby, V, Thompson, DR. A randomized trial comparing Arglaes (a transparent dressing containing silver ions) to Tegaderm (a transparent polyurethane dressing) for dressing peripheral arterial catheters and central vascular catheters. Intensive Critical Care Nursing 1998;14:187191.CrossRefGoogle ScholarPubMed
46.Zakrzewska-Bode, A, Muytiens, HL, Liem, KD, Hoogkamp-Korstanje, JA. Mupirocin resistance in coagulase-negative staphylococci, after topical prophylaxis for the reduction of colonization of central venous catheters. J Hosp Infect 1995;31:189193.Google Scholar
47.Flowers, RH, Schwenzer, KJ, Kopel, RF, Fisch, MJ, Tucker, SI, Farr, BM. Efficacy of an attachable subcutaneous cuff for the prevention of intravascular catheter-related infection: a randomized, controlled trial. JAMA 1989:261:878883.CrossRefGoogle ScholarPubMed
48.Robbins, J, Cromwell, P, Korones, DN. Swimming and central venous catheter-related infections in the child with cancer. J Pediatr Oncol Nurs 1999;16:5156.Google Scholar
49.Howell, PB, Walters, PE, Donowitz, GR, Farr, BM. Risk factors for infection of adult patients with cancer who have tunnelled central venous catheters. Cancer 1995;75:13671375.Google Scholar
50.Goetz, AM, Wagener, MM, Miller, JM, Muder, RR. Risk of infection due to central venous catheters: effect of site of placement and catheter type. Infect Control Hosp Epidemiol 1998;19:842845.Google Scholar
51.Trottier, SJ, Veremakis, C, O'Brien, J, Auer, AI. Femoral deep vein thrombosis associated with central venous catheterization: results from a prospective, randomized trial. Crit Care Med 1995;23:5259.Google Scholar
52.Goetz, AM, Miller, J, Wagener, MM, Muder, RR. Complications related to intravenous midline catheter usage: a 2-year study. Journal of Intravenous Nursing 1998;21:7680.Google Scholar
53.Martin, C, Viviand, X, Saux, P, Gouin, F. Upper-extremity deep vein thrombosis after central venous catheterization via the axillary vein. Crit Care Med 1999;27:26262629.Google Scholar
54.Robinson, JF, Robinson, WA, Cohn, AGarg, K, Armstrong, JD 2nd. Perforation of the great vessels during central venous line placement. Arch Intern Med 1995;155:12251228.Google Scholar
55.Lederle, FA, Parenti, CM, Berskow, LC, Ellingson, KJ. The idle intravenous catheter. Ann Intern Med 1992;116:737738.CrossRefGoogle ScholarPubMed
56.Parenti, CM, Lederle, FA, Impola, CL, Peterson, LR. Reduction of unnecessary intravenous catheter use: internal medicine house staff participate in a successful quality improvement project. Arch Intern Med 1994;154:18291832.Google Scholar
57.Cook, D, Randolph, A, Kernerman, P, et al. Central venous catheter replacement strategies: a systematic review of the literature. Crit Care Med 1997;25:14171424.Google Scholar
58.Cobb, DK, High, KP, Sawyer, RG, et al. A controlled trial of scheduled replacement of central venous and pulmonary-artery catheters. N Engl J Med 1992;327:10621068.Google Scholar
59.Thomas, F, Burke, JP, Parker, J, et al. The risk of infection related to radial vs femoral sites for arterial catheterization. Crit Care Med 1983;11:807812.CrossRefGoogle ScholarPubMed
60.Lai, KK. Safety of prolonging peripheral cannula and i.v. tubing use from 72 hours to 96 hours. Am J Infect Control 1998;26:6670.Google Scholar
61.Garland, JS, Dunne, WM Jr, Havens, P, et al. Peripheral intravenous catheter complications in critically ill children: a prospective study. Pediatrics 1992;89:11451150.Google Scholar
62.Garland, JS, Nelson, DB, Cheah, TE, Hennes, HH, Johnson, TM. Infectious complications during peripheral intravenous therapy with Teflon catheters: a prospective study. Pediatr Infect Dis J 1987;6:918921.CrossRefGoogle ScholarPubMed
63.Nelson, DB, Garland, JS. The natural history of Teflon catheter-associated phlebitis in children. Am J Dis Child 1987;141:10901092.Google Scholar
64.Shimandle, RB, Johnson, D, Baker, M, Stotland, N, Karrison, T, Arnow, PM. Safety of peripheral intravenous catheters in children. Infect Control Hosp Epidemiol 1999;20:736740.Google Scholar
65.O'Grady, NP, Barie, PS, Bartlett, J, et al. Practice parameters for evaluating new fever in critically ill adult patients: Task Force of the American College of Critical Care Medicine of the Society of Critical Care Medicine in collaboration with the Infectious Diseases Society of America. Crit Care Med 1998;26:392408.Google Scholar
66.Mermel, LA, Farr, BM, Sherertz, RJ, et al. Guidelines for the management of intravascular catheter-related infections. Clin Infect Dis 2001;32:12491272.Google Scholar
67.Sitges-Serra, ALinares, J, Perez, JL, Jaurrieta, E, Lorente, L. A randomized trial on the effect of tubing changes on hub contamination and catheter sepsis during parenteral nutrition. JPEN J Parenter Enteral Nutr 1985; 9:322325.Google Scholar
68.Josephson, A, Gombert, ME, Sierra, MF, Karanfil, LV, Tansino, GF. The relationship between intravenous fluid contamination and the frequency of tubing replacement. Infect Control 1985;6:367370.Google Scholar
69.Maki, DG, Botticelli, JT, LeRoy, ML, Thielke, TS. Prospective study of replacing administration sets for intravenous therapy at 48- vs 72-hour intervals: 72 hours is safe and cost-effective. JAMA 1987;258:17771781.Google Scholar
70.Snydman, DR, Donnelly-Reidy, M, Perry, LK, Martin, WJ. Intravenous tubing containing burettes can be safely changed at 72 hour intervals. Infect Control 1987;8:113116.Google Scholar
71.Melly, MA, Meng, HC, Schaffner, W. Microbiol growth in lipid emulsions used in parenteral nutrition. Arch Surg 1975;110:14791481.Google Scholar
72.Mershon, J, Nogami, W, Williams, JM, Yoder, C, Eitzen, HE, Lemons, JA. Bacterial/fungal growth in a combined parenteral nutrition solution. JPEN J Parenter Enteral Nutr 1986;10:498502.Google Scholar
73.Gilbert, M, Gallagher, SC, Eads, M, Elmore, MF. Microbial growth patterns in a total parenteral nutrition formulation containing lipid emulsion. JPEN J Parenter Enteral Nutr 1986;10:494497.Google Scholar
74.Maki, DG, Martin, WT. Nationwide epidemic of septicemia caused by contaminated infusion products: IV. Growth of microbial pathogens in fluids for intravenous infusions. J Infect Dis 1975;131:267272.Google Scholar
75.Didier, ME, Fischer, S, Maki, DG. Total nutrient admixtures appear safer than lipid emulsion alone as regards microbial contamination: growth properties of microbial pathogens at room temperature. JPEN J Parenter Enteral Nutr 1998;22:291296.Google Scholar
76.Bennett, SN, McNeil, MM, Bland, LA, et al. Postoperative infections traced to contamination of an intravenous anesthetic, propofol. N Engl J Med 1995;333:147154.CrossRefGoogle ScholarPubMed
77.Arduino, MJ, Bland, LA, Danzig, LE, McAllister, SK, Aguero, SM. Microbiologic evaluation of needleless and needle-access devices. Am J Infect Control 1997;25:377380.Google Scholar
78.Brown, JD, Moss, HA, Elliott, TS. The potential for catheter microbial contamination from a needleless connector. J Hosp Infect 1997;36:181189.Google Scholar
79.Cookson, ST, Ihrig, M, O'Mara, EM, et al. Increased bloodstream infection rates in surgical patients associated with variation from recommended use and care following implementation of a needleless device. Infect Control Hosp Epidemiol 1998;19:2327.Google Scholar
80.Luebke, MA, Arduino, MJ, Duda, DL, et al. Comparison of the microbial barrier properties of a needleless and a conventional needle-based intravenous access system. Am J Infect Control 1998;26:437441.Google Scholar
81.McDonald, LC, Banerjee, SN, Jarvis, WR. Line-associated bloodstream infections in pediatric intensive-care-unit patients associated with a needleless device and intermittent intravenous therapy. Infect Control Hosp Epidemiol 1998;19:772777.Google Scholar
82.Mendelson, MH, Short, LJ, Schechter, CB, et al. Study of a needleless intermittent intravenous-access system for peripheral infusions: analysis of staff, patient, and institutional outcomes. Infect Control Hosp Epidemiol 1998;19:401406.Google Scholar
83.Seymour, VM, Dhallu, TS, Moss, HATebbs, SE, Elliot, TS. A prospective clinical study to investigate the microbial contamination of a needleless connector. J Hosp Infect 2000;45:165168.Google Scholar
84.Do, AN, Ray, BJ, Banerjee, SN, et al. Bloodstream infection associated with needleless device use and the importance of infection-control practices in the home health care setting. J Infect Dis 1999;179:442448.Google Scholar
85.Crocker, KS, Noga, R, Filibeck, DJ, Krey, SH, Markovic, M, Steffee, WP. Microbial growth comparisons of five commercial parenteral lipid emulsions. JPEN J Parenter Enteral Nutr 1984;8:391395.Google Scholar
86.Jarvis, WR, Highsmith, AK. Bacterial growth and endotoxin production in lipid emulsion. J Clin Microbiol 1984;19:1720.Google Scholar
87.Roth, VR, Arduino, MJ, Nobiletti, J, et al. Transfusion-related sepsis due to Serratia liquefaciens in the United States. Transfusion 2000;40:931935.CrossRefGoogle ScholarPubMed
88.Blajchman, MA. Reducing the risk of bacterial contamination of cellular blood components. Dev Biol 2000;102:183193.Google ScholarPubMed
89.Barrett, BB, Andersen, JW, Anderson, KC. Strategies for the avoidance of bacterial contamination of blood components. Transfusion 1993;33:228233.Google Scholar
90.Wagner, SJ, Friedman, LI, Dodd, RY. Transfusion-associated bacterial sepsis. Clin Microbiol Rev 1994;7:290302.Google Scholar
91.Plott, RT, Wagner, RF Jr, Tyring, SK. Iatrogenic contamination of multi-dose vials in simulated use: a reassessment of current patient injection technique. Arch Dermatol 1990;126:14411444.Google Scholar
92.Salzman, MB, Isenberg, HD, Rubin, LG. Use of disinfectants to reduce microbial contamination of hubs of vascular catheters. J Clin Microbiol 1993;31:475479.Google Scholar
93.ASHP Council on Professional Affairs. ASHP guidelines on quality assurance for pharmacy-prepared sterile products. Am J Health Syst Pharm 2000;57:11501169.Google Scholar
94.Herruzo-Cabrera, R, Garcia-Caballero, J, Vera-Cortes, ML, et al. Growth of microorganisms in parenteral nutrient solutions. Am J Hosp Pharm 1984;41:11781180.Google Scholar
95.Green, KA, Mustachi, B, Schoer, K, Moro, D, Blend, R, McGeer, A. Gadolinium-based MR contrast media: potential for growth of microbial contaminants when single vials are used for multiple patients. AJR Am J Roentgenol 1995;165:669671.Google Scholar
96.Arlington, ME, Gabbert, KC, Mazgaj, FW, Wolf, MT. Multidose vial contamination in anesthesia. AANA J 1990;58:462466.Google Scholar
97.Maddox, RR, John, JF Jr, Brown, LL, Smith, CE. Effect of inline filtration on postinfusion phlebitis. Clin Pharm 1983;2:5861.Google Scholar
98.Falchuk, KH, Peterson, L, McNeil, BJ. Microparticulate-induced phlebitis: its prevention by in-line filtration. N Engl J Med 1985;312:7882.Google Scholar
99.Cohran, J, Larson, E, Roach, H, Blane, C, Pierce, P. Effect of intravascular surveillance and education program on rates of nosocomial bloodstream infections. Heart Lung 1996;25:161164.Google Scholar
100.McKee, R, Dunsmuir, R, Whitby, M, Garden, OJ. Does antibiotic prophylaxis at the time of catheter insertion reduce the incidence of catheter-related sepsis in intravenous nutrition? J Hosp Infect 1985;6:419425.Google Scholar
101.Ranson, MR, Oppenheim, BA, Jackson, A, Kamthan, AG, Scarffe, JH. Double-blind placebo controlled study of vancomycin prophylaxis for central venous catheter insertion in cancer patients. J Hosp Infect 1990;15:95102.Google Scholar
102.Miller, MA, Dascal, A, Portnoy, J, Mendelson, J. Development of mupirocin resistance among methicillin-resistant Staphylococcus aureus after widespread use of nasal mupirocin ointment. Infect Control Hosp Epidemiol 1996;17:811813.Google Scholar
103.Netto dos Santos, KR, de Souza Fonseca, L, Gontijo Filho, PP. Emergence of high-level mupirocin resistance in methicillin-resistant Staphylococcus aureus isolated from Brazilian university hospitals. Infect Control Hosp Epidemiol 1996;17:813816.Google Scholar
104.Band, JD, Maki, DG. Steel needles used for intravenous therapy: morbidity in patients with hematologic malignancy. Arch Intern Med 1980; 140:3134.Google Scholar
105.Tully, JL, Friedland, GH, Baldini, LM, Goldmann, DA. Complications of intravenous therapy with steel needles and Teflon catheters: a comparative study. Am J Med 1981;70:702706.Google Scholar
106.Ryder, MA. Peripheral access options. Surg Oncol Clin N Am 1995; 4:395427.Google Scholar
107.Maki, DG, Goldman, DA, Rhame, FS. Infection control in intravenous therapy. Ann Intern Med 1973;79:867887.Google Scholar
108.Maki, DG, Ringer, M. Risk factors for infusion-related phlebitis with small peripheral venous catheters: a randomized controlled trial. Ann Intern Med 1991;114:845854.CrossRefGoogle ScholarPubMed
109.Tager, IB, Ginsberg, MB, Ellis, SE, et al. An epidemiologic study of the risks associated with peripheral intravenous catheters. Am J Epidemiol 1983;118:839851.Google Scholar
110.Mermel, LA, Parenteau, S, Tow, SM. The risk of midline catheterization in hospitalized patients: a prospective study. Ann Intern Med 1995; 123:841844.Google Scholar
111.Centers for Disease Control and Prevention. National Nosocomial Infections Surveillance (NNIS) System report: data summary from October 1986-April 1998, issued June 1998. Am J Infect Control 1998; 26:522533.Google Scholar
112.Centers for Disease Control and Prevention. National Nosocomial Infections Surveillance (NNIS) System report: data summary from January 1990-May 1999, issued June 1999. Am J Infect Control 1999; 27:520532.Google Scholar
113.Banerjee, SN, Emori, TG, Culver, DH, et al. Secular trends in nosocomial primary bloodstream infections in the United States, 1980-1989: National Nosocomial Infections Surveillance System. Am J Med 1991; 91:86S89S.Google Scholar
114.Horan, TC, Emori, TG. Definitions of key terms used in the NNIS System. Am J Infect Control 1997;25:112116.Google Scholar
115.Khuri-Bulos, NA, Shennak, M, Agabi, S, et al. Nosocomial infections in the intensive care units at a university hospital in a developing country: comparison with National Nosocomial Infections Surveillance intensive care unit rates. Am J Infect Control 1999;27:547552.Google Scholar
116.Pittet, D, Wenzel, RP. Nosocomial bloodstream infections: secular trends in rates, mortality, and contribution to total hospital deaths. Arch Intern Med 1995;155:11771184.Google Scholar
117.Centers for Disease Control and Prevention. Monitoring hospital-acquired infections to promote patient safety: United States, 1990-1999. MMWR 2000;49:149153.Google Scholar
118.Joint Commission on the Accreditation of Healthcare Organizations. Accreditation Manual for Hospitals. Chicago: Joint Commission on the Accreditation of Healthcare Organizations; 1994:121140.Google Scholar
119.Clark-Christoff, N, Watters, VA, Sparks, W, Snyder, P, Grant, JP. Use of triple-lumen subclavian catheters for administration of total parenteral nutrition. JPEN J Parenter Enteral Nutr 1992;16:403407.Google Scholar
120.Early, TF, Gregory, RT, Wheeler, JR, Snyder, SO Jr, Gayle, RG. Increased infection rate in double-lumen versus single-lumen Hickman catheters in cancer patients. South Med J 1990;83:3436.Google Scholar
121.Hilton, E, Haslett, TM, Borenstein, MT, Tucci, V, Isenberg, HD, Singer, C. Central catheter infections: single- versus triple-lumen catheters. Influence of guide wires on infection rates when used for replacement of catheters. Am J Med 1988;84:667672.Google Scholar
122.Yeung, C, May, J, Hughes, R. Infection rate for single lumen v triple lumen subclavian catheters. Infect Control Hosp Epidemiol 1988;9:154158.Google Scholar
123.Raad, I, Darouiche, R, Dupuis, J, et al. Central venous catheters coated with minocycline and rifampin for the prevention of catheter-related colonization and bloodstream infections: a randomized, double-blind trial. The Texas Medical Center Catheter Study Group. Ann Intern Med 1997;127:267274.Google Scholar
124.Veenstra, DL, Saint, S, Saha, S, Lumley, T, Sullivan, SD. Efficacy of antiseptic-impregnated central venous catheters in preventing catheter-related bloodstream infection: a meta-analysis. JAMA 1999;281:261267.Google Scholar
125.Maki, DG, Stolz, SM, Wheeler, S, Mermel, LA. Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter: a randomized, controlled trial. Ann Intern Med 1997;127:257266.Google Scholar
126.Veenstra, DL, Saint, S, Sullivan, SD. Cost-effectiveness of antiseptic-impregnated central venous catheters for the prevention of catheter-related bloodstream infection. JAMA 1999;282:554560.Google Scholar
127.Darouiche, RO, Raad, II, Heard, SO, et al. A comparison of two antimicrobial-impregnated central venous catheters: Catheter Study Group. N Engl J Med 1999;340:18.Google Scholar
128.Collin, GR. Decreasing catheter colonization through the use of an antiseptic-impregnated catheter: a continuous quality improvement project. Chest 1999;115:16321640.Google Scholar
129.Groeger, JS, Lucas, AB, Thaler, HT, et al. Infectious morbidity associated with long-term use of venous access devices in patients with cancer. Ann Intern Med 1993;119:11681174.Google Scholar
130.Pegues, D, Axelrod, P, McClarren, C, et al. Comparison of infections in Hickman and implanted port catheters in adult solid tumor patients. J Surg Oncol 1992;49:156162.Google Scholar
131.Foundation, NK III. NKF-K/DOQI clinical practice guidelines for vascular access: update 2000. Am J Kidney Dis 2001;37:S137S181.Google Scholar
132.Moss, AH, Vasilakis, C, Holley, JL, Foulks, CJ, Pillai, K, McDowell, DE. Use of a silicone dual-lumen catheter with a Dacron cuff as a long-term vascular access for hemodialysis patients. Am J Kidney Dis 1990;16:211215.Google Scholar
132.Hoen, B, Paul-Dauphin, A, Hestin, D, Kessler, M. EPIBACDIAL: a multi-center prospective study of risk factors for bacteremia in chronic hemodialysis patients. J Am Soc Nephrol 1998;9:869876.Google Scholar
134.Levin, A, Mason, AJ, Jindal, KK, Fong, IW, Goldstein, MB. Prevention of hemodialysis subclavian vein catheter infections by topical povidone-iodine. Kidney Int 1991;40:934938.Google Scholar
135.Maki, DG, Band, JD. A comparative study of polyantibiotic and iodophor ointments in prevention of vascular catheter-related infection. Am J Med 1981;70:739744.Google Scholar
136.Merrer, J, De Jonghe, B, Golliot, F, et al. Complications of femoral and subclavian venous catheterization in critically ill patients: a randomized controlled trial. JAMA 2001;286:700707.Google Scholar
137.Venkataraman, ST, Thompson, AE, Orr, RA. Femoral vascular catheterization in critically ill infants and children. Clin Pediatr (Phila) 1997; 36:311319.Google Scholar
138.Stenzel, JP, Green, TP, Fuhrman, BP, Carlson, PE, Marchessault, RP. Percutaneous femoral venous catheterizations: a prospective study of complications. J Pediatr 1989;114:411415.Google Scholar
139.Goldstein, AM, Weber, JM, Sheridan, RL. Femoral venous access is safe in burned children: an analysis of 224 catheters. J Pediatr 1997; 130:442446.Google Scholar
140.Schillinger, F, Schillinger, D, Montagnac, R, Milcent, T. Post catheterisation vein stenosis in haemodialysis: comparative angiographic study of 50 subclavian and 50 internal jugular accesses. Nephrol Dial Transplant 1991;6:722724.Google Scholar
141.Cimochowski, GE, Worley, E, Rutherford, WE, Sartain, J, Blondin, J, Harter, H. Superiority of the internal jugular over the subclavian access for temporary dialysis. Nephron 1990;54:154161.Google Scholar
142.Barrett, N, Spencer, S, McIvor, J, Brown, EA. Subclavian stenosis: a major complication of subclavian dialysis catheters. Nephrol Dial Transplant 1988;3:423425.Google Scholar
143.Trerotola, SO, Kuhn-Fulton, J, Johnson, MS, Shah, H, Ambrosius, WT, Kneebone, PH. Tunneled infusion catheters: increased incidence of symptomatic venous thrombosis after subclavian versus internal jugular venous access. Radiology 2000;217:8993.Google Scholar
144.Macdonald, S, Watt, AJ, McNally, D, Edwards, RD, Moss, JG. Comparison of technical success and outcome of tunneled catheters inserted via the jugular and subclavian approaches. J Vase Interv Radiol 2000;11:225231.Google Scholar
145.Cohen, Y, Fosse, JP, Karoubi, P, et al. The “hands-off” catheter and the prevention of systemic infections associated with pulmonary artery catheter: a prospective study. Am J Respir Crit Care Med 1998;157:284287.Google Scholar
146.Eyer, S, Brummitt, C, Crossley, K, Siegel, R, Cerra, F. Catheter-related sepsis: prospective, randomized study of three methods of long-term catheter maintenance. Crit Care Med 1990;18:10731079.Google Scholar
147.Widmer, AF. Management of catheter-related bacteremia and fungemia in patients on total parenteral nutrition. Nutrition 1997;13:18S25S.Google Scholar
148.Powell, C, Kudsk, KA, Kulich, PA, Mandelbaum, JA, Fabri, PJ. Effect of frequent guidewire changes on triple-lumen catheter sepsis. JPEN J Parenter Enteral Nutr 1988;12:462464.CrossRefGoogle ScholarPubMed
149.Snydman, DR, Murray, SA, Kornfeld, SJ, Majka, JA, Ellis, CA. Total parenteral nutrition-related infections: prospective epidemiologic study using semiquantitative methods. Am J Med 1982;73:695699.Google Scholar
150.Henrickson, KJ, Axtell, RA, Hoover, SM, et al. Prevention of central venous catheter-related infections and thrombotic events in immunocompromised children by the use of vancomycin/ciprofloxacin/heparin flush solution: a randomized, multicenter, double-blind trial. J Clin Oncol 2000;18:12691278.Google Scholar
151.Carratala, J, Niubo, J, Fernandez-Sevilla, A, et al. Randomized, double-blind trial of an antibiotic-lock technique for prevention of gram-positive central venous catheter-related infection in neutropenic patients with cancer. Antimicrob Agents Chemother 1999;43:22002204.Google Scholar
152.Easom, A. Prophylactic antibiotic lock therapy for hemodialysis catheters. Nephrol Nurs J 2000;27:75.Google ScholarPubMed
153.Vercaigne, LM, Sitar, DS, Penner, SB, Bernstein, K, Wang, GQ, Burczynski, FJ. Antibiotic-heparin lock: in vitro antibiotic stability combined with heparin in a central venous catheter. Pharmacotherapy 2000;20:394399.Google Scholar
154.Maki, DG, Ringer, M. Evaluation of dressing regimens for prevention of infection with peripheral intravenous catheters: gauze, a transparent polyurethane dressing, and an iodophor-transparent dressing. JAMA 1987;258:23962403.Google Scholar
155.Garland, JS, Alex, CP, Mueller, CD, et al. A randomized trial comparing povidone-iodine to a chlorhexidine gluconate-impregnated dressing for prevention of central venous catheter infections in neonates. Pediatrics 2001;107:14311436.CrossRefGoogle ScholarPubMed
156.Rao, SP, Oreopoulos, DG. Unusual complications of a polyurethane PD catheter. Pent Dial Int 1997;17:410412.Google Scholar
157.Riu, S, Ruiz, CG, Martinez-Vea, A, Peralta, C, Oliver, JA. Spontaneous rupture of polyurethane peritoneal catheter: a possible deleterious effect of mupirocin ointment. Nephrol Dial Transplant 1998;13:18701871.Google Scholar
158.Donowitz, LG, Marsik, FJ, Hoyt, JW, Wenzel, RP. Serratia marcescens bacteremia from contaminated pressure transducers. JAMA 1979;242:17491751.Google Scholar
159.Luskin, RL, Weinstein, RA, Nathan, C, Chamberlin, WH, Kabins, SA. Extended use of disposable pressure transducers: a bacteriologie evaluation. JAMA 1986;255:916920.Google Scholar
160.Maki, DG, Hassemer, CA. Endemic rate of fluid contamination and related septicemia in arterial pressure monitoring. Am J Med 1981;70:733738.Google Scholar
161.Mermel, LAMaki, DG. Epidemic bloodstream infections from hemodynamic pressure monitoring: signs of the times. Infect Control Hosp Epidemiol 1989;10:4753.Google Scholar
162.Tenold, R, Priano, L, Kim, K, Rourke, B, Marrone, T. Infection potential of nondisposable pressure transducers prepared prior to use. Crit Care Med 1987;15:582583.Google Scholar
163.Raad, I, Umphrey, J, Khan, A, Truett, LJ, Bodey, GP. The duration of placement as a predictor of peripheral and pulmonary arterial catheter infections. J Hosp Infect 1993;23:1726.Google Scholar
164.Leroy, O, Billiau, V, Beuscart, C, et al. Nosocomial infections associated with long-term radial artery cannulation. Intensive Care Medicine 1989; 15:241246.Google Scholar
165.Fisher, MC, Long, SS, Roberts, EM, Dunn, JM, Balsara, RK. Pseudomonas maltophilia bacteremia in children undergoing open heart surgery. JAMA 1981;246:15711574.Google Scholar
166.Stamm, WE, Colella, JJ, Anderson, RL, Dixon, RE. Indwelling arterial catheters as a source of nosocomial bacteremia: an outbreak caused by Flavobacterium species. N Engl J Med 1975;292:10991102.Google Scholar
167.Weinstein, RA, Emori, TG, Anderson, RL, Stamm, WE. Pressure transducers as a source of bacteremia after open heart surgery: report of an outbreak and guidelines for prevention. Chest 1976;69:338344.Google Scholar
168.Shinozaki, T, Deane, RS, Mazuzan, JE Jr, Hamel, AJ, Hazelton, D. Bacterial contamination of arterial lines: a prospective study. JAMA 1983;249:223225.Google Scholar
169.Solomon, SL, Alexander, H, Eley, JW, et al. Nosocomial fungemia in neonates associated with intravascular pressure-monitoring devices. Pediatr Infect Dis 1986;5:680655.Google Scholar
170.Weems, JJ Jr, Chamberland, ME, Ward, J, Willy, M, Padhye, AA, Solomon, SL. Candida parapsilosis fungemia associated with parenteral nutrition and contaminated blood pressure transducers. J Clin Microbiol 1987; 25:10291032.Google Scholar
171.Beck-Sague, CM, Jarvis, WR, Brook, JH, et al. Epidemic bacteremia due to Acinetobacter baumannii in five intensive care units. Am J Epidemiol 1990;132:723733.Google Scholar
172.Villarino, ME, Jarvis, WR, O'Hara, C, Bresnahan, J, Clark, N. Epidemic of Serratia marcescens bacteremia in a cardiac intensive care unit. J Clin Microbiol 1989;27:24332436.Google Scholar
173.Boo, NY, Wong, NC, Zulkifli, SS, Lye, MS. Risk factors associated with umbilical vascular catheter-associated thrombosis in newborn infants. J Paediatr Child Health 1999;35:460465.Google Scholar
174.Krauss, AN, Albert, RF, Kannan, MM. Contamination of umbilical catheters in the newborn infant. J Pediatr 1970;77:965969.CrossRefGoogle ScholarPubMed
175.Landers, S, Moise, AA, Fraley, JK, Smith, EO, Baker, CJ. Factors associated with umbilical catheter-related sepsis in neonates. Am J Dis Child 1991;145:675680.Google Scholar
176.Cronin, WA, Germanson, TP, Donowitz, LG. Intravascular catheter colonization and related bloodstream infection in critically ill neonates. Infect Control Hosp Epidemiol 1990;11:301308.Google Scholar
177.Miller, KL, Coen, PE, White, WJ, Hurst, WJ, Achey, BE, Lang, CM. Effectiveness of skin absorption of tincture of I in blocking radioiodine from the human thyroid gland. Health Phys 1989;56:911914.Google Scholar
178.Ankola, PA, Atakent, YS. Effect of adding heparin in very low concentration to the infusate to prolong the patency of umbilical artery catheters. Am J Perinatol 1993;10:229232.Google Scholar
179.Horgan, MJ, Bartoletti, A, Polansky, S, Peters, JC, Manning, TJ, Lamont, BM. Effect of heparin infusates in umbilical arterial catheters on frequency of thrombotic complications. J Pediatr 1987;111:774778.Google Scholar
180.David, RJ, Merten, DF, Anderson, JC, Gross, S. Prevention of umbilical artery catheter clots with heparinized infusates. Dev Pharmacol Ther 1981;2:117126.Google Scholar
181.Fletcher, MA, Brown, DR, Landers, S, Seguin, J. Umbilical arterial catheter use: report of an audit conducted by the Study Group for Complications of Perinatal Care. Am J Perinatol 1994;11:9499.Google Scholar
182.Seguin, J, Fletcher, MA, Landers, S, Brown, D, Macpherson, T. Umbilical venous catheterizations: audit by the Study Group for Complications of Perinatal Care. Am J Perinatol 1994;11:6770.Google Scholar
183.Loisel, DB, Smith, MM, MacDonald, MG, Martin, GR. Intravenous access in newborn infants: impact of extended umbilical venous catheter use on requirement for peripheral venous lines. J Perinatol 1996;16:461466.Google Scholar