Case reportsPulmonary-renal syndrome in a newborn with placental transmission of ANCAs
Section snippets
Case report
A 32-year-old woman with a history of MPA was admitted during the 33rd week of her second pregnancy for evaluation of shortness of breath. She had been well throughout this pregnancy; however, 1 week before admission, she developed hypertension, and on admission, she reported a 1-day history of difficulty breathing.
The patient initially presented with pulmonary hemorrhage and glomerulonephritis 8 years before admission. MPO-ANCA level was elevated (42 U/mL; normal, <7 U/mL), and a renal biopsy
Discussion
MPA is a systemic disease characterized by vasculitis involving small blood vessels, particularly the glomerular and pulmonary capillaries. Clinical manifestations include necrotizing pauci-immune glomerulonephritis and pulmonary hemorrhage.2, 3, 4, 5 Despite clinical data suggesting a direct relationship between ANCAs and disease activity in patients with MPA,9, 10, 11, 12 the causal relationship between P-ANCAs specific for myeloperoxidase (MPO-ANCA) and disease manifestation has been
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Originally published online as doi:10.1053/j.ajkd.2005.01.001 on February 22, 2005.