Dermatologic SurgeryCutaneous squamous cell carcinoma treated with Mohs micrographic surgery in Australia I. Experience over 10 years
Section snippets
Methods
We conducted a prospective, noncomparative, multicenter, interventional case series of patients with cutaneous SCC treated with MMS in Australia and monitored by the SCFA between 1993 and 2002.
The selection criteria were all cases with histologically confirmed SCC and treated with MMS. The main data recorded were patient age and gender, reason for referral, duration of tumor, site, recurrences before MMS, preoperative tumor size, histological subtypes and evidence of perineural invasion, number
Patients treated with MMS
The study group included 1263 patients who underwent MMS for cutaneous SCC between 1993 and 2002. There were 324 women (25.7%) and 938 men (74.3%) (P < .0001), with a mean age of 66 ± 13 years (median, 68 years; range, 21-96 years). In 772 patients (61.1%) the lesion was a primary tumor, and in 491 patients (38.9%) the tumor was recurrent (previously treated with non-Mohs procedures; Table I).
The most commonly stated reasons for referral for MMS was tumor site (24.4%) and tumor recurrence
Discussion
The significant increase in the incidence of nonmelanoma skin cancers (NMSCs) over the past two decades has resulted in a growing number of studies on epidemiology, risk factors, and treatment modalities. SCC, which constitutes 20% to 25% of NMSC, is mainly associated with ultraviolet radiation, but other possible risk factors are ionizing radiation, chemical agents (arsenic, polycyclic aromatic hydrocarbons, smoking), genodermatoses (albinism and xeroderma pigmentosum), human papillomavirus
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Funding sources: None.
Conflicts of interest: None disclosed.