Clinical research studyTotal Antioxidant Capacity from Diet and Risk of Myocardial Infarction: A Prospective Cohort of Women
Section snippets
Ethics Statement
The Regional Ethical Review Board at Karolinska Institutet (Stockholm, Sweden) approved this investigation, and return of the self-administrated questionnaire was considered to imply informed consent to participate in the study.
Study Population
The Swedish Mammography Cohort was established between 1987 and 1990 among women residing in the Uppsala and Västmanland counties in central Sweden. All women born 1914-1948 were sent a questionnaire concerning diet, educational level, weight and height, and reproductive
Results
During the average 9.9 years of follow-up (321,434 person-years), we identified 1114 cases of incident myocardial infarction (the average age of first myocardial infarction was 75.7 years). Baseline characteristics of the women are presented in Table 1. Women with higher total antioxidant capacity of diet were more likely to be nonsmokers, have ≥12 years of education, and to have hypercholesterolemia. Regarding dietary characteristics, women in the highest quintile of total antioxidant capacity
Discussion
In this large prospective population-based cohort study, we observed that higher total antioxidant capacity of diet was statistically significantly associated with lower risk of incident myocardial infarction in a dose-response manner. Consumption of antioxidant-containing foods such as fruits and vegetables and whole grains were nonsignificantly inversely associated with the risk of myocardial infarction.
To our knowledge, this is the first study investigating dietary total antioxidant capacity
References (36)
- et al.
Cell signaling by reactive nitrogen and oxygen species in atherosclerosis
Free Radic Biol Med
(2000) - et al.
The pathophysiology of cigarette smoking and cardiovascular disease: an update
J Am Coll Cardiol
(2004) - et al.
Alcohol-induced oxidative stress
Life Sci
(2007) - et al.
Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies
J Nutr
(2006) - et al.
Randomised trial of alpha-tocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infarction
Lancet
(1997) - et al.
The validity and reproducibility of food-frequency questionnaire-based total antioxidant capacity estimates in Swedish women
Am J Clin Nutr
(2008) - et al.
Regression calibration method for correcting measurement-error bias in nutritional epidemiology
Am J Clin Nutr
(1997) - et al.
Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials
Am J Clin Nutr
(2008) Assessment of antioxidant capacity in vitro and in vivo
Free Radic Biol Med
(2010)- et al.
Atherosclerosis and oxidant stress: the end of the road for antioxidant vitamin treatment?
Cardiovasc Drugs Ther
(2007)
Blood radicals: reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system
Pharm Res
Inflammation and endothelial dysfunction during aging: role of NF-kappaB
J Appl Physiol
The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences
Clin Chem
Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance?
Hypertension
Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial
JAMA
Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial
JAMA
Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial
JAMA
A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study
Arch Intern Med
Cited by (81)
Oxidative stress in cardiac hypertrophy: From molecular mechanisms to novel therapeutic targets
2021, Free Radical Biology and MedicineHigher dietary total antioxidant capacity (TAC) reduces the risk of cardio-metabolic risk factors among adults: An updated systematic review and meta-analysis
2023, International Journal for Vitamin and Nutrition ResearchThe Inhibitory Effect of Sodium Bicarbonate, Phylex and Seaweed Extract Against Penicillium digitatum Causing Green Rot Disease in Local Lemon Fruits
2023, IOP Conference Series: Earth and Environmental Science
Funding: The study was supported by the Swedish Research Council for Infrastructure and the Swedish Council for Working Life and Social Research. The funders have not played a role in the study design, data collection, analysis, decision to publish, or preparation of the manuscript.
Conflict of Interest: None.
Authorship: All authors had access to the data and a role in writing the manuscript.