Arrhythmias and conduction disturbancesA New Scoring System for Evaluating the Risk of Heart Failure Events in Japanese Patients With Atrial Fibrillation
Section snippets
Methods
The Shinken Database was established for all new patients who visited The Cardiovascular Institute in Tokyo, Japan (Shinken is an abbreviated name in Japanese for the name of the hospital), and it excluded patients with active cancer and foreign travelers. The principal aim of this hospital-based database is to survey the prevalence and prognosis of cardiovascular diseases in patients in urban areas of Japan.5, 6 The registry was started in June 2004, and thereafter, patients have been
Results
The characteristics of the study patients (with AF; n = 1,942) are listed in Table 1. Patients with AF in the present study included 1,426 men (73%) and had a mean age of 66 years. Coexisting organic heart diseases were observed in approximately 1/3 of the patients with AF, and symptomatic HF was observed in approximately 20%.
During the average follow-up period of 776 ± 623 days, hospitalization or death with HF occurred in 147 patients (7.6%); 14 patients (0.7%) died from HF. The cumulative
Discussion
In the present study with Japanese patients with AF, we determined the cumulative incidence rates of HF events (hospitalization or death with HF). We also identified the independent predictors for HF events, consequently developing a new risk score, the H2ARDD score. The H2ARDD score stratified the risk for the incidence of HF events well, with a high predictive ability. The new risk score might aid in the identification of patients with AF at risk for the incidence of new hospitalization or
Acknowledgment
We thank Shiro Ueda and Nobuko Ueda at Medical Edge Company, Ltd., for assembling the database by the Clinical Study Supporting System and Ineko Hayakawa, Hiroaki Arai, and Hirokazu Aoki for data management and systems administration.
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Cited by (32)
Incidence and prediction of hospitalization for heart failure in patients with atrial fibrillation: the REFLEJA scale
2024, Revista Espanola de CardiologiaCardiovascular Events and Mortality in Patients With Atrial Fibrillation and Anemia (from the Fushimi AF Registry)
2020, American Journal of CardiologyAge-Dependent Prognostic Impact of Paroxysmal Versus Sustained Atrial Fibrillation on the Incidence of Cardiac Death and Heart Failure Hospitalization (the Fushimi AF Registry)
2019, American Journal of CardiologyCitation Excerpt :The differences in the predictors of subsequent HF event among the previous studies19–22 and the present study, may be partly due to differences in clinical backgrounds, enrollment periods, and study designs. For instance, 1 report21 included AF patients with pre-existing HF; New York Heart Association class 1; 14%, and class 2 to 4; 21% of the study population. The others19,20,22 did not include patients with pre-existing HF and evaluated the predictors of new-onset HF.
Diabetes mellitus, blood glucose and the risk of heart failure: A systematic review and meta-analysis of prospective studies
2018, Nutrition, Metabolism and Cardiovascular DiseasesCitation Excerpt :There was evidence of a nonlinear J-shaped association between blood glucose and heart failure, pnonlinearity<0.0001, with increased risk at a blood glucose concentration of 70 mg/dl (3.89 mmol/l) compared to 90 mg/dl (5.00 mmol/l) (summary RR = 1.40, 95% CI: 1.00–1.95), and from 110 mg/dl (6.11 mmol/l) and above with a dose–response relationship of increased risk with increasing blood glucose concentration (Fig. 3b, Supplementary Table 6). Forty one cohort studies (36 publications, 36 risk estimates) [35–66, 92–95] were included in the meta-analysis of diabetes mellitus and heart failure risk among patient populations including 100 284 cases and >613 925 participants (Fig. 3, Supplementary Table 4). One publication included data from 4 studies [42] and another publication included data from 3 studies [58].
This study was supported by grants from the St. Luke's Life Science Institute, Tokyo, Japan.