Coronary artery diseaseComparison of Diagnostic Accuracy of 64-Slice Computed Tomography Coronary Angiography in Women Versus Men With Angina Pectoris
Section snippets
Methods
During a 24-month period 402 patients with acute or stable chest pain symptoms who were referred for conventional coronary angiography (CCA) were included in the study. No patients with a history of percutaneous coronary intervention or coronary artery bypass surgery, impaired renal function (serum creatinine >120 μmol/L), persistent arrhythmias, and known intolerance to iodinated contrast material were included. CCA was performed before or after CTCA and served as the standard of reference.
Results
The analysis comprised 123 women and 279 men (Table 1). On average women were older (62 ± 11 vs 58 ± 11 years, p <0.01). Hypertension and diabetes were more frequent in women, with no significant difference for body mass index. There were more active smokers among men. Women had lower disease prevalence (51% vs 68%, p <0.01), which was defined as having ≥1 significant stenosis. The severity and extent of obstructive CAD was significantly lower in women compared with men (p <0.05), with fewer
Discussion
We demonstrated that the sensitivity of 64-slice CTCA to detect significant CAD was almost equally high in women and men (100% vs 99%) due to the very low occurrence of false-negative outcomes. Therefore, the diagnostic accuracy of 64-slice CTCA to rule out the presence of significant obstructive CAD was equally high in women and men and a negative CT scan reliably obviates the need for further downstream evaluation with invasive coronary angiography. The lower prevalence of CAD in women, with
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