FACTOR-VIII CONSUMPTION IN PRE-ECLAMPSIA
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Cited by (132)
Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways
2022, American Journal of Obstetrics and GynecologyCitation Excerpt :Inevitably, alternative clusters are grouped with an expanded range of disease definitions, for example, nonproteinuric preeclampsia. More than 40 years ago, we suggested that there may even be normotensive preeclampsia6 in which a cluster of preeclampsia features is present except hypertension. The diagnosis of a syndrome, including preeclampsia, has 1 aspect that is often disregarded.
Platelets, Coagulation, and the Liver
2021, Chesley’s Hypertensive Disorders in PregnancyThe risk of obstetrical syndromes after solid organ transplantation
2014, Best Practice and Research: Clinical Obstetrics and GynaecologyCitation Excerpt :Affected women have an increased ratio of thromboxane A2 relative to prostacyclin (PGI2) in their urine and elevated plasma levels of endothelin [28,29]. Importantly, elevated factor VIII consumption and increased levels of cellular fibronectin precede the onset of clinical manifestations in pregnancy [30,31]. Deep haemochorial placentation in the human requires decidualisation of the endometrium and extends to the inner myometrial spiral arteries in association with the invasion of the interstitial and later intravascular cytotrophoblast.
Platelets, coagulation, and the liver
2014, Chesley's Hypertensive Disorders in Pregnancy, Fourth EditionThrombocytopenia in Pregnancy
2013, PlateletsCoagulation and fibrinolytic system protein profiles in women with normal pregnancies and pregnancies complicated by hypertension
2012, Pregnancy HypertensionCitation Excerpt :The hypercoagulability of PE has been attributed to endothelial dysfunction, decreased antithrombin levels, and increased levels in markers of thrombin activity [9,11]. Other proteins involved in hemostasis such as factor VIII, soluble fibrin, thrombomodulin and D-dimer are also reported to be altered in PE [12–16]. The objective of the current study was to evaluate concentrations of coagulation and fibrinolytic system proteins longitudinally in nulliparous women prior to pregnancy and through pregnancy with a primary focus on the transition from the nonpregnant state to pregnancy.
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Present address: Department of Medicine, Royal Perth Hospital, Perth, Australia.